| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10010084 | HBV | ENSG00000292357.2 | protein_coding | CSF2RA | No | No | 1438 | P15509 |
| TVIS30073990 | HIV | ENSG00000292357.2 | protein_coding | CSF2RA | No | No | 1438 | P15509 |
| TVIS20064357 | HPV | ENSG00000198223.19 | protein_coding | CSF2RA | No | No | 1438 | P15509 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CSF2RA |
|---|---|
| DrugBank ID | DB00020 |
| Drug Name | Sargramostim |
| Target ID | BE0000628 |
| UniProt ID | P15509 |
| Regulation Type | agonist |
| PubMed IDs | 17090651; 16760463; 17522711; 16638185; 11752352 |
| Citations | Wang Y, Cai D, Brendel C, Barett C, Erben P, Manley PW, Hochhaus A, Neubauer A, Burchert A: Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2/STAT-5 pathway activation. Blood. 2007 Mar 1;109(5):2147-55. Epub 2006 Nov 7.@@Chen J, Carcamo JM, Golde DW: The alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor interacts with c-Kit and inhibits c-Kit signaling. J Biol Chem. 2006 Aug 4;281(31):22421-6. Epub 2006 Jun 7.@@Lencz T, Morgan TV, Athanasiou M, Dain B, Reed CR, Kane JM, Kucherlapati R, Malhotra AK: Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Mol Psychiatry. 2007 Jun;12(6):572-80. Epub 2007 Mar 20.@@Xiao R, Zhang R, Wang YL, Zhu ZL, Chen T, Yang JH: [Expression of soluble GM-CSF-Ralpha in patients with acute myeloid leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Apr;14(2):225-7.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational |
| Direct Classification | Peptides |
| SMILES | |
| Pathways | |
| PharmGKB | PA164748631 |
| ChEMBL | CHEMBL1201670 |
