| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10009977 | HBV | ENSG00000100243.22 | protein_coding | CYB5R3 | No | No | 1727 | P00387 |
| TVIS10009978 | HBV | ENSG00000100243.22 | protein_coding | CYB5R3 | No | No | 1727 | P00387 |
| TVIS10034784 | HBV | ENSG00000100243.22 | protein_coding | CYB5R3 | No | No | 1727 | P00387 |
| TVIS10047469 | HBV | ENSG00000100243.22 | protein_coding | CYB5R3 | No | No | 1727 | P00387 |
| TVIS30008207 | HIV | ENSG00000100243.22 | protein_coding | CYB5R3 | No | No | 1727 | P00387 |
| TVIS30055833 | HIV | ENSG00000100243.22 | protein_coding | CYB5R3 | No | No | 1727 | P00387 |
| TVIS44004197 | HTLV-1 | ENSG00000100243.22 | protein_coding | CYB5R3 | No | No | 1727 | P00387 |
| TVIS44014424 | HTLV-1 | ENSG00000100243.22 | protein_coding | CYB5R3 | No | No | 1727 | P00387 |
| TVIS44024191 | HTLV-1 | ENSG00000100243.22 | protein_coding | CYB5R3 | No | No | 1727 | P00387 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CYB5R3 |
|---|---|
| DrugBank ID | DB00157 |
| Drug Name | NADH |
| Target ID | BE0000160 |
| UniProt ID | P00387 |
| Regulation Type | |
| PubMed IDs | 16814740; 17082011; 17401193; 17040106; 17341833 |
| Citations | Roma GW, Crowley LJ, Barber MJ: Expression and characterization of a functional canine variant of cytochrome b5 reductase. Arch Biochem Biophys. 2006 Aug 1;452(1):69-82. Epub 2006 May 24.@@Nussenzveig RH, Lingam HB, Gaikwad A, Zhu Q, Jing N, Prchal JT: A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia. Haematologica. 2006 Nov;91(11):1542-5.@@Kim S, Suga M, Ogasahara K, Ikegami T, Minami Y, Yubisui T, Tsukihara T: Structure of Physarum polycephalum cytochrome b5 reductase at 1.56 A resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 1;63(Pt 4):274-9. Epub 2007 Mar 23.@@Kurian JR, Chin NA, Longlais BJ, Hayes KL, Trepanier LA: Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5. Chem Res Toxicol. 2006 Oct;19(10):1366-73.@@Ikegami T, Kameyama E, Yamamoto SY, Minami Y, Yubisui T: Structure and properties of the recombinant NADH-cytochrome b5 reductase of Physarum polycephalum. Biosci Biotechnol Biochem. 2007 Mar;71(3):783-90. Epub 2007 Mar 7. |
| Groups | Approved; Nutraceutical |
| Direct Classification | (5'->5')-dinucleotides |
| SMILES | NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O |
| Pathways | Ethylmalonic Encephalopathy; 3-Methylglutaconic Aciduria Type III; Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency); Caffeine Metabolism; Fructose and Mannose Degradation; Isovaleric Aciduria; Lysine Degradation; Methylmalonic Aciduria Due to Cobalamin-Related Disorders; Glycerol Phosphate Shuttle; Zellweger Syndrome; Propionic Acidemia; Glycolysis; Xanthine Dehydrogenase Deficiency (Xanthinuria); S-Adenosylhomocysteine (SAH) Hydrolase Deficiency; Tryptophan Metabolism; Glutaric Aciduria Type I; 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I; Glycine N-Methyltransferase Deficiency; Dimethylglycine Dehydrogenase Deficiency; Androgen and Estrogen Metabolism; Nucleotide Sugars Metabolism; 3-Methylglutaconic Aciduria Type IV; Dihydropyrimidine Dehydrogenase Deficiency (DHPD); Malate-Aspartate Shuttle; Folate Metabolism; Valine, Leucine, and Isoleucine Degradation; Maple Syrup Urine Disease; Glycerol Kinase Deficiency; Adenylosuccinate Lyase Deficiency; Cysteine Metabolism |
| PharmGKB | PA164755085 |
| ChEMBL | CHEMBL1234616 |
