| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30072899 | HIV | ENSG00000165168.9 | protein_coding | CYBB | No | No | 1536 | A0A0S2Z3S6 P04839 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CYBB |
|---|---|
| DrugBank ID | DB00514 |
| Drug Name | Dextromethorphan |
| Target ID | BE0004904 |
| UniProt ID | P15153 |
| Regulation Type | inhibitor |
| PubMed IDs | 14734632; 29581121 |
| Citations | Zhang W, Wang T, Qin L, Gao HM, Wilson B, Ali SF, Zhang W, Hong JS, Liu B: Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB J. 2004 Mar;18(3):589-91. Epub 2004 Jan 20.@@Chen CL, Cheng MH, Kuo CF, Cheng YL, Li MH, Chang CP, Wu JJ, Anderson R, Wang S, Tsai PJ, Liu CC, Lin YS: Dextromethorphan Attenuates NADPH Oxidase-Regulated Glycogen Synthase Kinase 3beta and NF-kappaB Activation and Reduces Nitric Oxide Production in Group A Streptococcal Infection. Antimicrob Agents Chemother. 2018 May 25;62(6). pii: AAC.02045-17. doi: 10.1128/AAC.02045-17. Print 2018 Jun. |
| Groups | Approved |
| Direct Classification | Morphinans |
| SMILES | [H][C@]12CCCC[C@]11CCN(C)[C@H]2CC2=C1C=C(OC)C=C2 |
| Pathways | |
| PharmGKB | PA449273 |
| ChEMBL | CHEMBL52440 |
