| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10013568 | HBV | ENSG00000151617.17 | protein_coding | EDNRA | No | No | 1909 | P25101 |
| TVIS20026127 | HPV | ENSG00000151617.17 | protein_coding | EDNRA | No | No | 1909 | P25101 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | EDNRA |
|---|---|
| DrugBank ID | DB00559 |
| Drug Name | Bosentan |
| Target ID | BE0000521 |
| UniProt ID | P25101 |
| Regulation Type | antagonist |
| PubMed IDs | 11728166; 11752352; 11447307; 11704565; 10961375; 11849873 |
| Citations | Albertini M, Lafortuna CL, Ciminaghi B, Mazzola S, Clement MG: Endothelin involvement in respiratory centre activity. Prostaglandins Leukot Essent Fatty Acids. 2001 Sep;65(3):157-63.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Kiowski W, Sutsch G, Oechslin E, Bertel O: Hemodynamic effects of bosentan in patients with chronic heart failure. Heart Fail Rev. 2001 Dec;6(4):325-34.@@Kramp R, Fourmanoir P, Caron N: Endothelin resets renal blood flow autoregulatory efficiency during acute blockade of NO in the rat. Am J Physiol Renal Physiol. 2001 Dec;281(6):F1132-40.@@Martin C, Held HD, Uhlig S: Differential effects of the mixed ET(A)/ET(B)-receptor antagonist bosentan on endothelin-induced bronchoconstriction, vasoconstriction and prostacyclin release. Naunyn Schmiedebergs Arch Pharmacol. 2000 Aug;362(2):128-36.@@Sihvola RK, Pulkkinen VP, Koskinen PK, Lemstrom KB: Crosstalk of endothelin-1 and platelet-derived growth factor in cardiac allograft arteriosclerosis. J Am Coll Cardiol. 2002 Feb 20;39(4):710-7. |
| Groups | Approved; Investigational |
| Direct Classification | Bipyrimidines and oligopyrimidines |
| SMILES | COC1=CC=CC=C1OC1=C(NS(=O)(=O)C2=CC=C(C=C2)C(C)(C)C)N=C(N=C1OCCO)C1=NC=CC=N1 |
| Pathways | |
| PharmGKB | PA10034 |
| ChEMBL | CHEMBL957 |
