| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30048684 | HIV | ENSG00000269858.6 | protein_coding | EGLN2 | No | No | 112398 | Q96KS0 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | EGLN2 |
|---|---|
| DrugBank ID | DB00126 |
| Drug Name | Ascorbic acid |
| Target ID | BE0002211 |
| UniProt ID | Q96KS0 |
| Regulation Type | cofactor |
| PubMed IDs | 17627474; 17627521; 29567393 |
| Citations | Nytko KJ, Spielmann P, Camenisch G, Wenger RH, Stiehl DP: Regulated function of the prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins. Antioxid Redox Signal. 2007 Sep;9(9):1329-38.@@Bruegge K, Jelkmann W, Metzen E: Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-alpha hydroxylases. Curr Med Chem. 2007;14(17):1853-62.@@Smirnoff N: Ascorbic acid metabolism and functions: A comparison of plants and mammals. Free Radic Biol Med. 2018 Jul;122:116-129. doi: 10.1016/j.freeradbiomed.2018.03.033. Epub 2018 Mar 20. |
| Groups | Approved; Nutraceutical |
| Direct Classification | Butenolides |
| SMILES | [H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO |
| Pathways | Tyrosine Metabolism; Refsum Disease; The Oncogenic Action of Succinate; Disulfiram Action Pathway; Aromatic L-Aminoacid Decarboxylase Deficiency; Oxidation of Branched-Chain Fatty Acids; Catecholamine Biosynthesis; Monoamine Oxidase-A Deficiency (MAO-A); Tyrosinemia, Transient, of the Newborn; Carnitine Synthesis; Phytanic Acid Peroxisomal Oxidation; Hawkinsinuria; Dopamine beta-Hydroxylase Deficiency; Tyrosinemia Type I; Alkaptonuria; Tyrosine Hydroxylase Deficiency; The Oncogenic Action of Fumarate |
| PharmGKB | PA451898 |
| ChEMBL | CHEMBL196 |
