| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30001670 | HIV | ENSG00000198734.12 | protein_coding | F5 | No | No | 2153 | P12259 |
| TVIS20014099 | HPV | ENSG00000198734.12 | protein_coding | F5 | No | No | 2153 | P12259 |
| TVIS20045389 | HPV | ENSG00000198734.12 | protein_coding | F5 | No | No | 2153 | P12259 |
| TVIS20068815 | HPV | ENSG00000198734.12 | protein_coding | F5 | No | No | 2153 | P12259 |
| TVIS44029608 | HTLV-1 | ENSG00000198734.12 | protein_coding | F5 | No | No | 2153 | P12259 |
| TVIS44021688 | HTLV-1 | ENSG00000198734.12 | protein_coding | F5 | No | No | 2153 | P12259 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | F5 |
|---|---|
| DrugBank ID | DB00055 |
| Drug Name | Drotrecogin alfa |
| Target ID | BE0000041 |
| UniProt ID | P12259 |
| Regulation Type | inhibitor |
| PubMed IDs | 11236773; 11714212; 11893230; 12004250; 12030642; 11752352; 6419799 |
| Citations | Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ Jr: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001 Mar 8;344(10):699-709.@@Kanji S, Devlin JW, Piekos KA, Racine E: Recombinant human activated protein C, drotrecogin alfa (activated): a novel therapy for severe sepsis. Pharmacotherapy. 2001 Nov;21(11):1389-402.@@Lyseng-Williamson KA, Perry CM: Drotrecogin alfa (activated). Drugs. 2002;62(4):617-30; discussion 631-2.@@Joyce DE, Grinnell BW: Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-kappaB. Crit Care Med. 2002 May;30(5 Suppl):S288-93.@@Poe K: Drotrecogin alfa (activated) approved for treatment of severe sepsis. J Am Pharm Assoc (Wash). 2002 May-Jun;42(3):520-2.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Fulcher CA, Gardiner JE, Griffin JH, Zimmerman TS: Proteolytic inactivation of human factor VIII procoagulant protein by activated human protein C and its analogy with factor V. Blood. 1984 Feb;63(2):486-9. |
| Groups | Approved; Investigational; Withdrawn |
| Direct Classification | Peptides |
| SMILES | |
| Pathways | |
| PharmGKB | PA131548935 |
| ChEMBL |
