| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10036000 | HBV | ENSG00000185010.15 | protein_coding | F8 | No | No | 2157 | P00451 |
| TVIS10031972 | HBV | ENSG00000185010.15 | protein_coding | F8 | No | No | 2157 | P00451 |
| TVIS30010023 | HIV | ENSG00000185010.15 | protein_coding | F8 | No | No | 2157 | P00451 |
| TVIS30000259 | HIV | ENSG00000185010.15 | protein_coding | F8 | No | No | 2157 | P00451 |
| TVIS30073897 | HIV | ENSG00000185010.15 | protein_coding | F8 | No | No | 2157 | P00451 |
| TVIS30073898 | HIV | ENSG00000185010.15 | protein_coding | F8 | No | No | 2157 | P00451 |
| TVIS30073899 | HIV | ENSG00000185010.15 | protein_coding | F8 | No | No | 2157 | P00451 |
| TVIS30073900 | HIV | ENSG00000185010.15 | protein_coding | F8 | No | No | 2157 | P00451 |
| TVIS30073901 | HIV | ENSG00000185010.15 | protein_coding | F8 | No | No | 2157 | P00451 |
| TVIS30073902 | HIV | ENSG00000185010.15 | protein_coding | F8 | No | No | 2157 | P00451 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | F8 |
|---|---|
| DrugBank ID | DB00055 |
| Drug Name | Drotrecogin alfa |
| Target ID | BE0000016 |
| UniProt ID | P00451 |
| Regulation Type | inhibitor |
| PubMed IDs | 9184404; 18954704; 11752352; 6419799 |
| Citations | Geng JP, Castellino FJ: Properties of a recombinant chimeric protein in which the gamma-carboxyglutamic acid and helical stack domains of human anticoagulant protein C are replaced by those of human coagulation factor VII. Thromb Haemost. 1997 May;77(5):926-33.@@Colin G, Annane D: Corticosteroids and human recombinant activated protein C for septic shock. Clin Chest Med. 2008 Dec;29(4):705-12, x. doi: 10.1016/j.ccm.2008.06.009.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Fulcher CA, Gardiner JE, Griffin JH, Zimmerman TS: Proteolytic inactivation of human factor VIII procoagulant protein by activated human protein C and its analogy with factor V. Blood. 1984 Feb;63(2):486-9. |
| Groups | Approved; Investigational; Withdrawn |
| Direct Classification | Peptides |
| SMILES | |
| Pathways | |
| PharmGKB | PA131548935 |
| ChEMBL |
