| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30018607 | HIV | ENSG00000134824.14 | protein_coding | FADS2 | No | No | 9415 | O95864 |
| TVIS30088106 | HIV | ENSG00000134824.14 | protein_coding | FADS2 | No | No | 9415 | O95864 |
| TVIS30029682 | HIV | ENSG00000134824.14 | protein_coding | FADS2 | No | No | 9415 | O95864 |
| TVIS30029683 | HIV | ENSG00000134824.14 | protein_coding | FADS2 | No | No | 9415 | O95864 |
| TVIS30029684 | HIV | ENSG00000134824.14 | protein_coding | FADS2 | No | No | 9415 | O95864 |
| TVIS44000601 | HTLV-1 | ENSG00000134824.14 | protein_coding | FADS2 | No | No | 9415 | O95864 |
| TVIS44013958 | HTLV-1 | ENSG00000134824.14 | protein_coding | FADS2 | No | No | 9415 | O95864 |
| TVIS44020447 | HTLV-1 | ENSG00000134824.14 | protein_coding | FADS2 | No | No | 9415 | O95864 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | FADS2 |
|---|---|
| DrugBank ID | DB00132 |
| Drug Name | alpha-Linolenic acid |
| Target ID | BE0002246 |
| UniProt ID | O95864 |
| Regulation Type | ligand |
| PubMed IDs | 17409318; 16988497; 17284757; 15481543; 12713571; 21210105 |
| Citations | Portolesi R, Powell BC, Gibson RA: Competition between 24:5n-3 and ALA for Delta 6 desaturase may limit the accumulation of DHA in HepG2 cell membranes. J Lipid Res. 2007 Jul;48(7):1592-8. Epub 2007 Apr 4.@@Xiang M, Rahman MA, Ai H, Li X, Harbige LS: Diet and gene expression: delta-5 and delta-6 desaturases in healthy Chinese and European subjects. Ann Nutr Metab. 2006;50(6):492-8. Epub 2006 Sep 19.@@Baylin A, Ruiz-Narvaez E, Kraft P, Campos H: alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. Am J Clin Nutr. 2007 Feb;85(2):554-60.@@Li MC, Bu YP, Wang GK, Hu GW, Xing LJ: [Heteologous expression of Mortierella isabellina delta6 -fatty acid desaturase gene in soybean]. Yi Chuan Xue Bao. 2004 Aug;31(8):858-63.@@Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM: Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity. J Invest Dermatol. 2003 May;120(5):707-14.@@Tan L, Meesapyodsuk D, Qiu X: Molecular analysis of 6 desaturase and 6 elongase from Conidiobolus obscurus in the biosynthesis of eicosatetraenoic acid, a omega3 fatty acid with nutraceutical potentials. Appl Microbiol Biotechnol. 2011 Apr;90(2):591-601. doi: 10.1007/s00253-010-3060-y. Epub 2011 Jan 6. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | Lineolic acids and derivatives |
| SMILES | CCC=C/CC=C/CC=C/CCCCCCCC(O)=O |
| Pathways | Alpha Linolenic Acid and Linoleic Acid Metabolism |
| PharmGKB | PA449384 |
| ChEMBL | CHEMBL8739 |
