| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10006324 | HBV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
| TVIS10003145 | HBV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
| TVIS10022102 | HBV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
| TVIS10025984 | HBV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
| TVIS10051965 | HBV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
| TVIS10052093 | HBV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
| TVIS30025272 | HIV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
| TVIS30025273 | HIV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | FDPS |
|---|---|
| DrugBank ID | DB00282 |
| Drug Name | Pamidronic acid |
| Target ID | BE0000776 |
| UniProt ID | P14324 |
| Regulation Type | inhibitor |
| PubMed IDs | 11752352; 10620343; 11160603; 15713990; 12177810; 15487700 |
| Citations | Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Bergstrom JD, Bostedor RG, Masarachia PJ, Reszka AA, Rodan G: Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys. 2000 Jan 1;373(1):231-41.@@Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH, Rogers MJ: Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther. 2001 Feb;296(2):235-42.@@Notarnicola M, Messa C, Cavallini A, Bifulco M, Tecce MF, Eletto D, Di Leo A, Montemurro S, Laezza C, Caruso MG: Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis. Oncology. 2004;67(5-6):351-8.@@Riebeling C, Forsea AM, Raisova M, Orfanos CE, Geilen CC: The bisphosphonate pamidronate induces apoptosis in human melanoma cells in vitro. Br J Cancer. 2002 Jul 29;87(3):366-71.@@Zhang PL, Lun M, Siegelmann-Danieli N, Blasick TM, Brown RE: Pamidronate resistance and associated low ras levels in breast cancer cells: a role for combinatorial therapy. Ann Clin Lab Sci. 2004 Summer;34(3):263-70. |
| Groups | Approved |
| Direct Classification | Bisphosphonates |
| SMILES | NCCC(O)(P(O)(O)=O)P(O)(O)=O |
| Pathways | Pamidronate Action Pathway |
| PharmGKB | PA450767 |
| ChEMBL | CHEMBL834 |
