| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30005893 | HIV | ENSG00000110203.10 | protein_coding | FOLR3 | No | No | 2352 | P41439 |
| TVIS20010260 | HPV | ENSG00000110203.10 | protein_coding | FOLR3 | No | No | 2352 | P41439 |
| TVIS20028006 | HPV | ENSG00000110203.10 | protein_coding | FOLR3 | No | No | 2352 | P41439 |
| TVIS20069734 | HPV | ENSG00000110203.10 | protein_coding | FOLR3 | No | No | 2352 | P41439 |
| TVIS20068780 | HPV | ENSG00000110203.10 | protein_coding | FOLR3 | No | No | 2352 | P41439 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | FOLR3 |
|---|---|
| DrugBank ID | DB00158 |
| Drug Name | Folic acid |
| Target ID | BE0000652 |
| UniProt ID | P41439 |
| Regulation Type | binder |
| PubMed IDs | 17139284; 17016423; 8110752; 7727426; 8061055; 11752352 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Shen F, Ross JF, Wang X, Ratnam M: Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. Biochemistry. 1994 Feb 8;33(5):1209-15.@@Shen F, Wu M, Ross JF, Miller D, Ratnam M: Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity. Biochemistry. 1995 Apr 25;34(16):5660-5.@@Prasad PD, Ramamoorthy S, Moe AJ, Smith CH, Leibach FH, Ganapathy V: Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. Biochim Biophys Acta. 1994 Aug 11;1223(1):71-5.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Nutraceutical; Vet_approved |
| Direct Classification | Glutamic acid and derivatives |
| SMILES | NC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1 |
| Pathways | Methotrexate Action Pathway; Folate Metabolism; Methylenetetrahydrofolate Reductase Deficiency (MTHFRD); Folate Malabsorption, Hereditary |
| PharmGKB | PA449692 |
| ChEMBL | CHEMBL1622 |
