| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20003375 | HPV | ENSG00000204681.11 | protein_coding | GABBR1 | No | No | 2550 | Q5SUJ9 Q8IW08 Q9UBS5 |
| TVIS20006860 | HPV | ENSG00000204681.11 | protein_coding | GABBR1 | No | No | 2550 | Q5SUJ9 Q8IW08 Q9UBS5 |
| TVIS44022560 | HTLV-1 | ENSG00000204681.11 | protein_coding | GABBR1 | No | No | 2550 | Q5SUJ9 Q8IW08 Q9UBS5 |
| TVIS44022561 | HTLV-1 | ENSG00000204681.11 | protein_coding | GABBR1 | No | No | 2550 | Q5SUJ9 Q8IW08 Q9UBS5 |
| TVIS44050516 | HTLV-1 | ENSG00000204681.11 | protein_coding | GABBR1 | No | No | 2550 | Q5SUJ9 Q8IW08 Q9UBS5 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | GABBR1 |
|---|---|
| DrugBank ID | DB00181 |
| Drug Name | Baclofen |
| Target ID | BE0000217 |
| UniProt ID | Q9UBS5 |
| Regulation Type | agonist |
| PubMed IDs | 8388192; 10386831; 19303900; 10444662; 10482760; 10494996; 10545129; 10094428; 22559224; 16182939; 17011315 |
| Citations | Bowery NG: GABAB receptor pharmacology. Annu Rev Pharmacol Toxicol. 1993;33:109-47.@@Garcia-Gil L, de Miguel R, Romero J, Perez A, Ramos JA, Fernandez-Ruiz JJ: Perinatal delta9-tetrahydrocannabinol exposure augmented the magnitude of motor inhibition caused by GABA(B), but not GABA(A), receptor agonists in adult rats. Neurotoxicol Teratol. 1999 May-Jun;21(3):277-83.@@Lehmann A: GABAB receptors as drug targets to treat gastroesophageal reflux disease. Pharmacol Ther. 2009 Jun;122(3):239-45. doi: 10.1016/j.pharmthera.2009.02.008. Epub 2009 Mar 19.@@Motalli R, Louvel J, Tancredi V, Kurcewicz I, Wan-Chow-Wah D, Pumain R, Avoli M: GABA(B) receptor activation promotes seizure activity in the juvenile rat hippocampus. J Neurophysiol. 1999 Aug;82(2):638-47.@@Mott DD, Li Q, Okazaki MM, Turner DA, Lewis DV: GABAB-Receptor-mediated currents in interneurons of the dentate-hilus border. J Neurophysiol. 1999 Sep;82(3):1438-50.@@Ogasawara T, Itoh Y, Tamura M, Mushiroi T, Ukai Y, Kise M, Kimura K: Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer. Pharmacol Biochem Behav. 1999 Sep;64(1):41-52.@@Pittman QJ: The action is at the terminal. J Physiol. 1999 Nov 1;520 Pt 3:629.@@Stringer JL, Lorenzo N: The reduction in paired-pulse inhibition in the rat hippocampus by gabapentin is independent of GABA(B) receptor receptor activation. Epilepsy Res. 1999 Feb;33(2-3):169-76.@@Fu Z, Yang H, Xiao Y, Zhao G, Huang H: The gamma-aminobutyric acid type B (GABAB) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens. Behav Brain Funct. 2012 Jul 10;8:20. doi: 10.1186/1744-9081-8-20.@@Chen K, Li HZ, Ye N, Zhang J, Wang JJ: Role of GABAB receptors in GABA and baclofen-induced inhibition of adult rat cerebellar interpositus nucleus neurons in vitro. Brain Res Bull. 2005 Oct 30;67(4):310-8. doi: 10.1016/j.brainresbull.2005.07.004.@@Omari TI, Benninga MA, Sansom L, Butler RN, Dent J, Davidson GP: Effect of baclofen on esophagogastric motility and gastroesophageal reflux in children with gastroesophageal reflux disease: a randomized controlled trial. J Pediatr. 2006 Oct;149(4):468-74. doi: 10.1016/j.jpeds.2006.05.029. |
| Groups | Approved |
| Direct Classification | Gamma amino acids and derivatives |
| SMILES | NCC(CC(O)=O)C1=CC=C(Cl)C=C1 |
| Pathways | |
| PharmGKB | PA448533 |
| ChEMBL | CHEMBL701 |
