| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10017835 | HBV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS10049964 | HBV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS30004190 | HIV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS30079024 | HIV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS30075830 | HIV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS30082812 | HIV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS30020969 | HIV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS20007944 | HPV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS20063531 | HPV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS20018278 | HPV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | GABBR2 |
|---|---|
| DrugBank ID | DB00181 |
| Drug Name | Baclofen |
| Target ID | BE0002340 |
| UniProt ID | O75899 |
| Regulation Type | agonist |
| PubMed IDs | 15235087; 8388192; 10751439; 19303900; 10328880; 10545129; 22559224; 16182939 |
| Citations | Braun M, Wendt A, Buschard K, Salehi A, Sewing S, Gromada J, Rorsman P: GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin. J Physiol. 2004 Sep 1;559(Pt 2):397-409. Epub 2004 Jul 2.@@Bowery NG: GABAB receptor pharmacology. Annu Rev Pharmacol Toxicol. 1993;33:109-47.@@Filippov AK, Couve A, Pangalos MN, Walsh FS, Brown DA, Moss SJ: Heteromeric assembly of GABA(B)R1 and GABA(B)R2 receptor subunits inhibits Ca(2+) current in sympathetic neurons. J Neurosci. 2000 Apr 15;20(8):2867-74.@@Lehmann A: GABAB receptors as drug targets to treat gastroesophageal reflux disease. Pharmacol Ther. 2009 Jun;122(3):239-45. doi: 10.1016/j.pharmthera.2009.02.008. Epub 2009 Mar 19.@@Martin SC, Russek SJ, Farb DH: Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1. Mol Cell Neurosci. 1999 Mar;13(3):180-91.@@Pittman QJ: The action is at the terminal. J Physiol. 1999 Nov 1;520 Pt 3:629.@@Fu Z, Yang H, Xiao Y, Zhao G, Huang H: The gamma-aminobutyric acid type B (GABAB) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens. Behav Brain Funct. 2012 Jul 10;8:20. doi: 10.1186/1744-9081-8-20.@@Chen K, Li HZ, Ye N, Zhang J, Wang JJ: Role of GABAB receptors in GABA and baclofen-induced inhibition of adult rat cerebellar interpositus nucleus neurons in vitro. Brain Res Bull. 2005 Oct 30;67(4):310-8. doi: 10.1016/j.brainresbull.2005.07.004. |
| Groups | Approved |
| Direct Classification | Gamma amino acids and derivatives |
| SMILES | NCC(CC(O)=O)C1=CC=C(Cl)C=C1 |
| Pathways | |
| PharmGKB | PA448533 |
| ChEMBL | CHEMBL701 |
