| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10015168 | HBV | ENSG00000135423.13 | protein_coding | GLS2 | No | No | 27165 | A0A087X004 Q9UI32 |
| TVIS10015169 | HBV | ENSG00000135423.13 | protein_coding | GLS2 | No | No | 27165 | A0A087X004 Q9UI32 |
| TVIS10026882 | HBV | ENSG00000135423.13 | protein_coding | GLS2 | No | No | 27165 | A0A087X004 Q9UI32 |
| TVIS10026883 | HBV | ENSG00000135423.13 | protein_coding | GLS2 | No | No | 27165 | A0A087X004 Q9UI32 |
| TVIS10026884 | HBV | ENSG00000135423.13 | protein_coding | GLS2 | No | No | 27165 | A0A087X004 Q9UI32 |
| TVIS10026885 | HBV | ENSG00000135423.13 | protein_coding | GLS2 | No | No | 27165 | A0A087X004 Q9UI32 |
| TVIS10049961 | HBV | ENSG00000135423.13 | protein_coding | GLS2 | No | No | 27165 | A0A087X004 Q9UI32 |
| TVIS30033215 | HIV | ENSG00000135423.13 | protein_coding | GLS2 | No | No | 27165 | A0A087X004 Q9UI32 |
| TVIS20034424 | HPV | ENSG00000135423.13 | protein_coding | GLS2 | No | No | 27165 | A0A087X004 Q9UI32 |
| TVIS44026809 | HTLV-1 | ENSG00000135423.13 | protein_coding | GLS2 | No | No | 27165 | A0A087X004 Q9UI32 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | GLS2 |
|---|---|
| DrugBank ID | DB00142 |
| Drug Name | Glutamic acid |
| Target ID | BE0000003 |
| UniProt ID | Q9UI32 |
| Regulation Type | |
| PubMed IDs | 17373776; 17321558; 16793004 |
| Citations | Dossena L, Curti B, Vanoni MA: Activation and coupling of the glutaminase and synthase reaction of glutamate synthase is mediated by E1013 of the ferredoxin-dependent enzyme, belonging to loop 4 of the synthase domain. Biochemistry. 2007 Apr 17;46(15):4473-85. Epub 2007 Mar 21.@@Kita K, Suzuki T, Ochi T: Down-regulation of glutaminase C in human hepatocarcinoma cell by diphenylarsinic acid, a degradation product of chemical warfare agents. Toxicol Appl Pharmacol. 2007 May 1;220(3):262-70. Epub 2007 Jan 24.@@Yoshimune K, Shirakihara Y, Shiratori A, Wakayama M, Chantawannakul P, Moriguchi M: Crystal structure of a major fragment of the salt-tolerant glutaminase from Micrococcus luteus K-3. Biochem Biophys Res Commun. 2006 Aug 11;346(4):1118-24. Epub 2006 Jun 6. |
| Groups | Approved; Nutraceutical |
| Direct Classification | Glutamic acid and derivatives |
| SMILES | N[C@@H](CCC(O)=O)C(O)=O |
| Pathways | Histidinemia; Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); 3-Methylglutaconic Aciduria Type I; beta-Ketothiolase Deficiency; Purine Nucleoside Phosphorylase Deficiency; Tyrosine Metabolism; Ketoprofen Action Pathway; Glutamate Metabolism; Argininosuccinic Aciduria; Salla Disease/Infantile Sialic Acid Storage Disease; Tyrosinemia Type I; Hyperinsulinism-Hyperammonemia Syndrome; 2-Methyl-3-hydroxybutryl-CoA Dehydrogenase Deficiency; Glutaric Aciduria Type I; Propanoate Metabolism; Celecoxib Action Pathway; Glycine and Serine Metabolism; Suprofen Action Pathway; Indomethacin Action Pathway; Carbamoyl Phosphate Synthetase Deficiency; Sialuria or French Type Sialuria; Ibuprofen Action Pathway; Saccharopinuria/Hyperlysinemia II; Histidine Metabolism; Arginine and Proline Metabolism; Purine Metabolism; Diflunisal Action Pathway; Etodolac Action Pathway; Ammonia Recycling |
| PharmGKB | PA449776 |
| ChEMBL | CHEMBL575060 |
