| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30004537 | HIV | ENSG00000063854.13 | protein_coding | HAGH | No | No | 3029 | Q16775 |
| TVIS30015173 | HIV | ENSG00000063854.13 | protein_coding | HAGH | No | No | 3029 | Q16775 |
| TVIS30018680 | HIV | ENSG00000063854.13 | protein_coding | HAGH | No | No | 3029 | Q16775 |
| TVIS30018192 | HIV | ENSG00000063854.13 | protein_coding | HAGH | No | No | 3029 | Q16775 |
| TVIS30074010 | HIV | ENSG00000063854.13 | protein_coding | HAGH | No | No | 3029 | Q16775 |
| TVIS30039912 | HIV | ENSG00000063854.13 | protein_coding | HAGH | No | No | 3029 | Q16775 |
| TVIS30039913 | HIV | ENSG00000063854.13 | protein_coding | HAGH | No | No | 3029 | Q16775 |
| TVIS30039914 | HIV | ENSG00000063854.13 | protein_coding | HAGH | No | No | 3029 | Q16775 |
| TVIS30039915 | HIV | ENSG00000063854.13 | protein_coding | HAGH | No | No | 3029 | Q16775 |
| TVIS30039916 | HIV | ENSG00000063854.13 | protein_coding | HAGH | No | No | 3029 | Q16775 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HAGH |
|---|---|
| DrugBank ID | DB00143 |
| Drug Name | Glutathione |
| Target ID | BE0001825 |
| UniProt ID | Q16775 |
| Regulation Type | |
| PubMed IDs | 17139284; 17016423; 11018726; 8589803; 3955057 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Ridderstrom M, Jemth P, Cameron AD, Mannervik B: The active-site residue tyr-175 in human glyoxalase II contributes to binding of glutathione derivatives. Biochim Biophys Acta. 2000 Sep 29;1481(2):344-8.@@Chyan MK, Elia AC, Principato GB, Giovannini E, Rosi G, Norton SJ: S-fluorenylmethoxycarbonyl glutathione and diesters: inhibition of mammalian glyoxalase II. Enzyme Protein. 1994-1995;48(3):164-73.@@Al-Timari A, Douglas KT: Inhibition by glutathione derivatives of bovine liver glyoxalase II (hydroxyacylglutathione hydrolase) as a probe of the N- and S-sites for substrate binding. Biochim Biophys Acta. 1986 Mar 28;870(2):219-25. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | Peptides |
| SMILES | N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O |
| Pathways | Arachidonic Acid Metabolism; Flurbiprofen Action Pathway; 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency; Oxaprozin Action Pathway; Rofecoxib Action Pathway; Pyruvate Kinase Deficiency; Acetaminophen Metabolism Pathway; Mefenamic Acid Action Pathway; Bromfenac Action Pathway; 5-Oxoprolinuria; gamma-Glutamyltransferase Deficiency; Naproxen Action Pathway; Sulindac Action Pathway; Glutathione Synthetase Deficiency; Piroxicam Action Pathway; Nabumetone Action Pathway; 2-Hydroxyglutric Aciduria (D and L Form); Meloxicam Action Pathway; Cyclophosphamide Action Pathway; Succinic Semialdehyde Dehydrogenase Deficiency; Valdecoxib Action Pathway; Ketorolac Action Pathway; 5-Oxoprolinase Deficiency; Acetylsalicylic Acid Action Pathway; Antipyrine Action Pathway; Glutathione Metabolism; Diclofenac Action Pathway; Homocarnosinosis; Cyclophosphamide Metabolism Pathway; Nepafenac Action Pathway |
| PharmGKB | PA449780 |
| ChEMBL | CHEMBL1543 |
