| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20014000 | HPV | ENSG00000150540.14 | protein_coding | HNMT | No | No | 3176 | P50135 |
| TVIS20054793 | HPV | ENSG00000150540.14 | protein_coding | HNMT | No | No | 3176 | P50135 |
| TVIS44005329 | HTLV-1 | ENSG00000150540.14 | protein_coding | HNMT | No | No | 3176 | P50135 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HNMT |
|---|---|
| DrugBank ID | DB00613 |
| Drug Name | Amodiaquine |
| Target ID | BE0002436 |
| UniProt ID | P50135 |
| Regulation Type | inhibitor |
| PubMed IDs | 17222819; 6789797; 1203620; 11752352 |
| Citations | Yokoyama A, Mori S, Takahashi HK, Kanke T, Wake H, Nishibori M: Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84. Epub 2006 Nov 22.@@Nowak JZ, Zandarowska E: Effect of amodiaquine on histamine level and histamine-methyltransferase activity in the rat brain. Arch Immunol Ther Exp (Warsz). 1980;28(6):927-30.@@Barth H, Lorenz W, Troidl H: Effect of amodiaquine on gastric histamine methyltransferase and on histamine-stimulated gastric secretion. Br J Pharmacol. 1975 Nov;55(3):321-7.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational |
| Direct Classification | 4-aminoquinolines |
| SMILES | CCN(CC)CC1=C(O)C=CC(NC2=C3C=CC(Cl)=CC3=NC=C2)=C1 |
| Pathways | |
| PharmGKB | PA448404 |
| ChEMBL | CHEMBL682 |
