| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10036737 | HBV | ENSG00000158104.11 | protein_coding | HPD | No | No | 3242 | P32754 |
| TVIS10019453 | HBV | ENSG00000158104.11 | protein_coding | HPD | No | No | 3242 | P32754 |
| TVIS10019452 | HBV | ENSG00000158104.11 | protein_coding | HPD | No | No | 3242 | P32754 |
| TVIS10018392 | HBV | ENSG00000158104.11 | protein_coding | HPD | No | No | 3242 | P32754 |
| TVIS10047501 | HBV | ENSG00000158104.11 | protein_coding | HPD | No | No | 3242 | P32754 |
| TVIS10047502 | HBV | ENSG00000158104.11 | protein_coding | HPD | No | No | 3242 | P32754 |
| TVIS30034353 | HIV | ENSG00000158104.11 | protein_coding | HPD | No | No | 3242 | P32754 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HPD |
|---|---|
| DrugBank ID | DB00348 |
| Drug Name | Nitisinone |
| Target ID | BE0000455 |
| UniProt ID | P32754 |
| Regulation Type | inhibitor |
| PubMed IDs | 11752352; 15931360; 14668946; 12142814; 15931605; 18422479 |
| Citations | Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Fisher AA, Davis MW: Alkaptonuric ochronosis with aortic valve and joint replacements and femoral fracture: a case report and literature review. Clin Med Res. 2004 Nov;2(4):209-15.@@Yang DY: 4-Hydroxyphenylpyruvate dioxygenase as a drug discovery target. Drug News Perspect. 2003 Oct;16(8):493-6.@@Hanauske-Abel HM, Popowicz A, Remotti H, Newfield RS, Levy J: Tyrosinemia I, a model for human diseases mediated by 2-oxoacid-utilizing dioxygenases: hepatotoxin suppression by NTBC does not normalize hepatic collagen metabolism. J Pediatr Gastroenterol Nutr. 2002 Jul;35(1):73-8.@@Suwannarat P, O'Brien K, Perry MB, Sebring N, Bernardini I, Kaiser-Kupfer MI, Rubin BI, Tsilou E, Gerber LH, Gahl WA: Use of nitisinone in patients with alkaptonuria. Metabolism. 2005 Jun;54(6):719-28.@@Santra S, Baumann U: Experience of nitisinone for the pharmacological treatment of hereditary tyrosinaemia type 1. Expert Opin Pharmacother. 2008 May;9(7):1229-36. doi: 10.1517/14656566.9.7.1229. |
| Groups | Approved; Investigational |
| Direct Classification | Benzoylcyclohexane-1,3-diones |
| SMILES | [O-][N+](=O)C1=C(C=CC(=C1)C(F)(F)F)C(=O)C1C(=O)CCCC1=O |
| Pathways | |
| PharmGKB | PA164777037 |
| ChEMBL | CHEMBL1337 |
