| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10018748 | HBV | ENSG00000080824.19 | protein_coding | HSP90AA1 | Yes | No | 3320 | P07900 |
| TVIS30037413 | HIV | ENSG00000080824.19 | protein_coding | HSP90AA1 | Yes | No | 3320 | P07900 |
| TVIS30037414 | HIV | ENSG00000080824.19 | protein_coding | HSP90AA1 | Yes | No | 3320 | P07900 |
| TVIS20052009 | HPV | ENSG00000080824.19 | protein_coding | HSP90AA1 | Yes | No | 3320 | P07900 |
| TVIS20030653 | HPV | ENSG00000080824.19 | protein_coding | HSP90AA1 | Yes | No | 3320 | P07900 |
| TVIS44033980 | HTLV-1 | ENSG00000080824.19 | protein_coding | HSP90AA1 | Yes | No | 3320 | P07900 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | HSP90AA1 |
|---|---|
| DrugBank ID | DB00615 |
| Drug Name | Rifabutin |
| Target ID | BE0001120 |
| UniProt ID | P07900 |
| Regulation Type | other/unknown |
| PubMed IDs | 10701840; 10759403; 10919672; 11306472; 11358819 |
| Citations | Schnaider T, Somogyi J, Csermely P, Szamel M: The Hsp90-specific inhibitor geldanamycin selectively disrupts kinase-mediated signaling events of T-lymphocyte activation. Cell Stress Chaperones. 2000 Jan;5(1):52-61.@@Neckers L, Schulte TW, Mimnaugh E: Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity. Invest New Drugs. 1999;17(4):361-73.@@Srethapakdi M, Liu F, Tavorath R, Rosen N: Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest. Cancer Res. 2000 Jul 15;60(14):3940-6.@@Munster PN, Srethapakdi M, Moasser MM, Rosen N: Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells. Cancer Res. 2001 Apr 1;61(7):2945-52.@@Yang J, Yang JM, Iannone M, Shih WJ, Lin Y, Hait WN: Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin. Cancer Res. 2001 May 15;61(10):4010-6. |
| Groups | Approved; Investigational |
| Direct Classification | Macrolactams |
| SMILES | CO[C@H]1C=CO[C@@]2(C)OC3=C(C2=O)C2=C(C(O)=C3C)C(=O)C(NC(=O)C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)=C1NC3(CCN(CC3)CC(C)C)N=C21 |
| Pathways | |
| PharmGKB | PA451249 |
| ChEMBL | CHEMBL444633 |
