| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30076603 | HIV | ENSG00000067704.10 | protein_coding | IARS2 | No | No | 55699 | Q9NSE4 |
| TVIS30026556 | HIV | ENSG00000067704.10 | protein_coding | IARS2 | No | No | 55699 | Q9NSE4 |
| TVIS30026557 | HIV | ENSG00000067704.10 | protein_coding | IARS2 | No | No | 55699 | Q9NSE4 |
| TVIS30026558 | HIV | ENSG00000067704.10 | protein_coding | IARS2 | No | No | 55699 | Q9NSE4 |
| TVIS30026559 | HIV | ENSG00000067704.10 | protein_coding | IARS2 | No | No | 55699 | Q9NSE4 |
| TVIS20039529 | HPV | ENSG00000067704.10 | protein_coding | IARS2 | No | No | 55699 | Q9NSE4 |
| TVIS20017384 | HPV | ENSG00000067704.10 | protein_coding | IARS2 | No | No | 55699 | Q9NSE4 |
| TVIS44037111 | HTLV-1 | ENSG00000067704.10 | protein_coding | IARS2 | No | No | 55699 | Q9NSE4 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | IARS2 |
|---|---|
| DrugBank ID | DB00167 |
| Drug Name | Isoleucine |
| Target ID | BE0002328 |
| UniProt ID | Q9NSE4 |
| Regulation Type | |
| PubMed IDs | 12783542; 14672940; 17095543; 15663927; 16697013 |
| Citations | Wang P, Tang Y, Tirrell DA: Incorporation of trifluoroisoleucine into proteins in vivo. J Am Chem Soc. 2003 Jun 11;125(23):6900-6.@@Fukunaga R, Fukai S, Ishitani R, Nureki O, Yokoyama S: Crystal structures of the CP1 domain from Thermus thermophilus isoleucyl-tRNA synthetase and its complex with L-valine. J Biol Chem. 2004 Feb 27;279(9):8396-402. Epub 2003 Dec 12.@@Zhu B, Zhao MW, Eriani G, Wang ED: A present-day aminoacyl-tRNA synthetase with ancestral editing properties. RNA. 2007 Jan;13(1):15-21. Epub 2006 Nov 9.@@Fukunaga R, Yokoyama S: Crystal structure of leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshii reveals a novel editing domain orientation. J Mol Biol. 2005 Feb 11;346(1):57-71. Epub 2004 Dec 19.@@Fukunaga R, Yokoyama S: Structural basis for substrate recognition by the editing domain of isoleucyl-tRNA synthetase. J Mol Biol. 2006 Jun 16;359(4):901-12. Epub 2006 Apr 25. |
| Groups | Investigational; Nutraceutical |
| Direct Classification | Isoleucine and derivatives |
| SMILES | CC[C@H](C)[C@H](N)C(O)=O |
| Pathways | 3-Methylglutaconic Aciduria Type III; 3-Methylglutaconic Aciduria Type I; beta-Ketothiolase Deficiency; Demeclocycline Action Pathway; Josamycin Action Pathway; Gentamicin Action Pathway; Lincomycin Action Pathway; Isobutyryl-CoA Dehydrogenase Deficiency; Methacycline Action Pathway; Clarithromycin Action Pathway; Minocycline Action Pathway; Paromomycin Action Pathway; Lymecycline Action Pathway; 2-Methyl-3-hydroxybutryl-CoA Dehydrogenase Deficiency; 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency; Troleandomycin Action Pathway; Amikacin Action Pathway; Methylmalonic Aciduria; Oxytetracycline Action Pathway; Tetracycline Action Pathway; Spectinomycin Action Pathway; Doxycycline Action Pathway; 3-Methylglutaconic Aciduria Type IV; Telithromycin Action Pathway; Roxithromycin Action Pathway; Tigecycline Action Pathway; Valine, Leucine, and Isoleucine Degradation; Arbekacin Action Pathway; Isovaleric Acidemia; Chloramphenicol Action Pathway |
| PharmGKB | PA164750430 |
| ChEMBL | CHEMBL1233584 |
