| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10015691 | HBV | ENSG00000134460.19 | protein_coding | IL2RA | No | No | 3559 | P01589 Q5W005 |
| TVIS10026184 | HBV | ENSG00000134460.19 | protein_coding | IL2RA | No | No | 3559 | P01589 Q5W005 |
| TVIS30011403 | HIV | ENSG00000134460.19 | protein_coding | IL2RA | No | No | 3559 | P01589 Q5W005 |
| TVIS30004372 | HIV | ENSG00000134460.19 | protein_coding | IL2RA | No | No | 3559 | P01589 Q5W005 |
| TVIS30010128 | HIV | ENSG00000134460.19 | protein_coding | IL2RA | No | No | 3559 | P01589 Q5W005 |
| TVIS20032371 | HPV | ENSG00000134460.19 | protein_coding | IL2RA | No | No | 3559 | P01589 Q5W005 |
| TVIS20040966 | HPV | ENSG00000134460.19 | protein_coding | IL2RA | No | No | 3559 | P01589 Q5W005 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | IL2RA |
|---|---|
| DrugBank ID | DB00004 |
| Drug Name | Denileukin diftitox |
| Target ID | BE0000658 |
| UniProt ID | P01589 |
| Regulation Type | binder |
| PubMed IDs | 2786749; 3124610; 18684057; 17187516 |
| Citations | Kiyokawa T, Shirono K, Hattori T, Nishimura H, Yamaguchi K, Nichols JC, Strom TB, Murphy JR, Takatsuki K: Cytotoxicity of interleukin 2-toxin toward lymphocytes from patients with adult T-cell leukemia. Cancer Res. 1989 Jul 15;49(14):4042-6.@@Murphy JR, Kelley VE, Strom TB: Interleukin 2 toxin: a step toward selective immunomodulation. Am J Kidney Dis. 1988 Feb;11(2):159-62.@@Duvic M, Talpur R: Optimizing denileukin diftitox (Ontak) therapy. Future Oncol. 2008 Aug;4(4):457-69. doi: 10.2217/14796694.4.4.457.@@Turturro F: Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders. Expert Rev Anticancer Ther. 2007 Jan;7(1):11-7. |
| Groups | Approved; Investigational |
| Direct Classification | Peptides |
| SMILES | |
| Pathways | |
| PharmGKB | PA164750594 |
| ChEMBL | CHEMBL1201550 |
