| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30004110 | HIV | ENSG00000133731.10 | protein_coding | IMPA1 | No | No | 3612 | P29218 |
| TVIS30069203 | HIV | ENSG00000133731.10 | protein_coding | IMPA1 | No | No | 3612 | P29218 |
| TVIS20062851 | HPV | ENSG00000133731.10 | protein_coding | IMPA1 | No | No | 3612 | P29218 |
| TVIS44011524 | HTLV-1 | ENSG00000133731.10 | protein_coding | IMPA1 | No | No | 3612 | P29218 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | IMPA1 |
|---|---|
| DrugBank ID | DB01356 |
| Drug Name | Lithium cation |
| Target ID | BE0001152 |
| UniProt ID | P29218 |
| Regulation Type | inhibitor |
| PubMed IDs | 16874097; 16965760; 17068342; 17158747; 17251911; 20027624 |
| Citations | Sarkar S, Rubinsztein DC: Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations. Autophagy. 2006 Apr-Jun;2(2):132-4. Epub 2006 Apr 6.@@Trinquet E, Fink M, Bazin H, Grillet F, Maurin F, Bourrier E, Ansanay H, Leroy C, Michaud A, Durroux T, Maurel D, Malhaire F, Goudet C, Pin JP, Naval M, Hernout O, Chretien F, Chapleur Y, Mathis G: D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation. Anal Biochem. 2006 Nov 1;358(1):126-35. Epub 2006 Aug 30.@@Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T: Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. J Biol Chem. 2007 Jan 5;282(1):637-46. Epub 2006 Oct 26.@@Tanizawa Y, Kuhara A, Inada H, Kodama E, Mizuno T, Mori I: Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans. Genes Dev. 2006 Dec 1;20(23):3296-310.@@Ohnishi T, Yamada K, Ohba H, Iwayama Y, Toyota T, Hattori E, Inada T, Kunugi H, Tatsumi M, Ozaki N, Iwata N, Sakamoto K, Iijima Y, Iwata Y, Tsuchiya KJ, Sugihara G, Nanko S, Osumi N, Detera-Wadleigh SD, Kato T, Yoshikawa T: A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription. Neuropsychopharmacology. 2007 Aug;32(8):1727-37. Epub 2007 Jan 24.@@Li Z, Stieglitz KA, Shrout AL, Wei Y, Weis RM, Stec B, Roberts MF: Mobile loop mutations in an archaeal inositol monophosphatase: modulating three-metal ion assisted catalysis and lithium inhibition. Protein Sci. 2010 Feb;19(2):309-18. doi: 10.1002/pro.315. |
| Groups | Experimental |
| Direct Classification | Homogeneous alkali metal compounds |
| SMILES | [Li+] |
| Pathways | |
| PharmGKB | PA450243 |
| ChEMBL | CHEMBL1234004 |
