| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10008852 | HBV | ENSG00000115232.14 | protein_coding | ITGA4 | No | No | 3676 | P13612 |
| TVIS30003207 | HIV | ENSG00000115232.14 | protein_coding | ITGA4 | No | No | 3676 | P13612 |
| TVIS30003208 | HIV | ENSG00000115232.14 | protein_coding | ITGA4 | No | No | 3676 | P13612 |
| TVIS30051895 | HIV | ENSG00000115232.14 | protein_coding | ITGA4 | No | No | 3676 | P13612 |
| TVIS30051896 | HIV | ENSG00000115232.14 | protein_coding | ITGA4 | No | No | 3676 | P13612 |
| TVIS30051897 | HIV | ENSG00000115232.14 | protein_coding | ITGA4 | No | No | 3676 | P13612 |
| TVIS20054320 | HPV | ENSG00000115232.14 | protein_coding | ITGA4 | No | No | 3676 | P13612 |
| TVIS20029523 | HPV | ENSG00000115232.14 | protein_coding | ITGA4 | No | No | 3676 | P13612 |
| TVIS20030522 | HPV | ENSG00000115232.14 | protein_coding | ITGA4 | No | No | 3676 | P13612 |
| TVIS20029524 | HPV | ENSG00000115232.14 | protein_coding | ITGA4 | No | No | 3676 | P13612 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ITGA4 |
|---|---|
| DrugBank ID | DB00108 |
| Drug Name | Natalizumab |
| Target ID | BE0000590 |
| UniProt ID | P13612 |
| Regulation Type | antibody |
| PubMed IDs | 16268663; 16634035; 17461891; 9389694; 11752352 |
| Citations | Sheremata WA, Minagar A, Alexander JS, Vollmer T: The role of alpha-4 integrin in the aetiology of multiple sclerosis: current knowledge and therapeutic implications. CNS Drugs. 2005;19(11):909-22.@@Niino M, Bodner C, Simard ML, Alatab S, Gano D, Kim HJ, Trigueiro M, Racicot D, Guerette C, Antel JP, Fournier A, Grand'Maison F, Bar-Or A: Natalizumab effects on immune cell responses in multiple sclerosis. Ann Neurol. 2006 May;59(5):748-54.@@Stuve O, Bennett JL: Pharmacological properties, toxicology and scientific rationale for the use of natalizumab (Tysabri) in inflammatory diseases. CNS Drug Rev. 2007 Spring;13(1):79-95.@@Craddock CF, Nakamoto B, Andrews RG, Priestley GV, Papayannopoulou T: Antibodies to VLA4 integrin mobilize long-term repopulating cells and augment cytokine-induced mobilization in primates and mice. Blood. 1997 Dec 15;90(12):4779-88.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational |
| Direct Classification | Peptides |
| SMILES | |
| Pathways | |
| PharmGKB | PA164747191 |
| ChEMBL | CHEMBL1201607 |
