| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44047927 | HTLV-1 | ENSG00000104783.15 | protein_coding | KCNN4 | No | No | 3783 | O15554 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | KCNN4 |
|---|---|
| DrugBank ID | DB00257 |
| Drug Name | Clotrimazole |
| Target ID | BE0000415 |
| UniProt ID | O15554 |
| Regulation Type | inhibitor |
| PubMed IDs | 8636434; 10428416; 8903326 |
| Citations | Brugnara C, Gee B, Armsby CC, Kurth S, Sakamoto M, Rifai N, Alper SL, Platt OS: Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease. J Clin Invest. 1996 Mar 1;97(5):1227-34.@@Wu SN, Li HF, Jan CR, Shen AY: Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells. Neuropharmacology. 1999 Jul;38(7):979-89.@@Rufo PA, Jiang L, Moe SJ, Brugnara C, Alper SL, Lencer WI: The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells. J Clin Invest. 1996 Nov 1;98(9):2066-75. doi: 10.1172/JCI119012. |
| Groups | Approved; Vet_approved |
| Direct Classification | Triphenyl compounds |
| SMILES | ClC1=CC=CC=C1C(N1C=CN=C1)(C1=CC=CC=C1)C1=CC=CC=C1 |
| Pathways | |
| PharmGKB | PA449057 |
| ChEMBL | CHEMBL104 |
