| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20050198 | HPV | ENSG00000170421.13 | protein_coding | KRT8 | No | No | 3856 | P05787 |
| TVIS44046814 | HTLV-1 | ENSG00000170421.13 | protein_coding | KRT8 | No | No | 3856 | P05787 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | KRT8 |
|---|---|
| DrugBank ID | DB00031 |
| Drug Name | Tenecteplase |
| Target ID | BE0002105 |
| UniProt ID | P05787 |
| Regulation Type | |
| PubMed IDs | 9988531; 8760360; 8810346 |
| Citations | Kralovich KR, Li L, Hembrough TA, Webb DJ, Karns LR, Gonias SL: Characterization of the binding sites for plasminogen and tissue-type plasminogen activator in cytokeratin 8 and cytokeratin 18. J Protein Chem. 1998 Nov;17(8):845-54.@@Hembrough TA, Kralovich KR, Li L, Gonias SL: Cytokeratin 8 released by breast carcinoma cells in vitro binds plasminogen and tissue-type plasminogen activator and promotes plasminogen activation. Biochem J. 1996 Aug 1;317 ( Pt 3):763-9.@@Hembrough TA, Li L, Gonias SL: Cell-surface cytokeratin 8 is the major plasminogen receptor on breast cancer cells and is required for the accelerated activation of cell-associated plasminogen by tissue-type plasminogen activator. J Biol Chem. 1996 Oct 11;271(41):25684-91. |
| Groups | Approved |
| Direct Classification | Peptides |
| SMILES | |
| Pathways | Tenecteplase Action Pathway |
| PharmGKB | PA164776757 |
| ChEMBL | CHEMBL2108791 |
