| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10011544 | HBV | ENSG00000115919.15 | protein_coding | KYNU | No | No | 8942 | Q16719 |
| TVIS10011545 | HBV | ENSG00000115919.15 | protein_coding | KYNU | No | No | 8942 | Q16719 |
| TVIS10003394 | HBV | ENSG00000115919.15 | protein_coding | KYNU | No | No | 8942 | Q16719 |
| TVIS10021827 | HBV | ENSG00000115919.15 | protein_coding | KYNU | No | No | 8942 | Q16719 |
| TVIS10028721 | HBV | ENSG00000115919.15 | protein_coding | KYNU | No | No | 8942 | Q16719 |
| TVIS20005639 | HPV | ENSG00000115919.15 | protein_coding | KYNU | No | No | 8942 | Q16719 |
| TVIS20017819 | HPV | ENSG00000115919.15 | protein_coding | KYNU | No | No | 8942 | Q16719 |
| TVIS44004105 | HTLV-1 | ENSG00000115919.15 | protein_coding | KYNU | No | No | 8942 | Q16719 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | KYNU |
|---|---|
| DrugBank ID | DB00114 |
| Drug Name | Pyridoxal phosphate |
| Target ID | BE0000392 |
| UniProt ID | Q16719 |
| Regulation Type | cofactor |
| PubMed IDs | 14756555; 12204580; 17300176; 11985583 |
| Citations | Momany C, Levdikov V, Blagova L, Lima S, Phillips RS: Three-dimensional structure of kynureninase from Pseudomonas fluorescens. Biochemistry. 2004 Feb 10;43(5):1193-203.@@Rooseboom M, Vermeulen NP, Groot EJ, Commandeur JN: Tissue distribution of cytosolic beta-elimination reactions of selenocysteine Se-conjugates in rat and human. Chem Biol Interact. 2002 Aug 15;140(3):243-64.@@Lima S, Khristoforov R, Momany C, Phillips RS: Crystal structure of Homo sapiens kynureninase. Biochemistry. 2007 Mar 13;46(10):2735-44. Epub 2007 Feb 15.@@Walsh HA, Botting NP: Purification and biochemical characterization of some of the properties of recombinant human kynureninase. Eur J Biochem. 2002 Apr;269(8):2069-74. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | Pyridoxals and derivatives |
| SMILES | CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O |
| Pathways | Histidinemia; 3-Methylglutaconic Aciduria Type I; Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); beta-Ketothiolase Deficiency; Tyrosine Metabolism; Disulfiram Action Pathway; Hyperprolinemia Type II; Glutamate Metabolism; Argininosuccinic Aciduria; Tyrosinemia Type I; Hyperinsulinism-Hyperammonemia Syndrome; Porphyrin Metabolism; 2-Methyl-3-hydroxybutryl-CoA Dehydrogenase Deficiency; Glutaric Aciduria Type I; Propanoate Metabolism; Taurine and Hypotaurine Metabolism; Catecholamine Biosynthesis; Glycine and Serine Metabolism; Carnitine Synthesis; Tyrosinemia Type 3 (TYRO3); Selenoamino Acid Metabolism; Carbamoyl Phosphate Synthetase Deficiency; Hyperprolinemia Type I; Saccharopinuria/Hyperlysinemia II; Histidine Metabolism; Cystathionine beta-Synthase Deficiency; Arginine and Proline Metabolism; Starch and Sucrose Metabolism; Globoid Cell Leukodystrophy; Ammonia Recycling |
| PharmGKB | PA164749650 |
| ChEMBL | CHEMBL82202 |
