| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30003494 | HIV | ENSG00000011376.12 | protein_coding | LARS2 | No | No | 23395 | Q15031 |
| TVIS30056753 | HIV | ENSG00000011376.12 | protein_coding | LARS2 | No | No | 23395 | Q15031 |
| TVIS30056754 | HIV | ENSG00000011376.12 | protein_coding | LARS2 | No | No | 23395 | Q15031 |
| TVIS30056755 | HIV | ENSG00000011376.12 | protein_coding | LARS2 | No | No | 23395 | Q15031 |
| TVIS30056756 | HIV | ENSG00000011376.12 | protein_coding | LARS2 | No | No | 23395 | Q15031 |
| TVIS30056757 | HIV | ENSG00000011376.12 | protein_coding | LARS2 | No | No | 23395 | Q15031 |
| TVIS30056758 | HIV | ENSG00000011376.12 | protein_coding | LARS2 | No | No | 23395 | Q15031 |
| TVIS30056759 | HIV | ENSG00000011376.12 | protein_coding | LARS2 | No | No | 23395 | Q15031 |
| TVIS30056760 | HIV | ENSG00000011376.12 | protein_coding | LARS2 | No | No | 23395 | Q15031 |
| TVIS30056761 | HIV | ENSG00000011376.12 | protein_coding | LARS2 | No | No | 23395 | Q15031 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | LARS2 |
|---|---|
| DrugBank ID | DB00149 |
| Drug Name | Leucine |
| Target ID | BE0000204 |
| UniProt ID | Q15031 |
| Regulation Type | |
| PubMed IDs | 17144674; 17095543; 17407263; 16774921; 17378584 |
| Citations | Ma JJ, Zhao MW, Wang ED: Split leucine-specific domain of leucyl-tRNA synthetase from the hyperthermophilic bacterium Aquifex aeolicus. Biochemistry. 2006 Dec 12;45(49):14809-16.@@Zhu B, Zhao MW, Eriani G, Wang ED: A present-day aminoacyl-tRNA synthetase with ancestral editing properties. RNA. 2007 Jan;13(1):15-21. Epub 2006 Nov 9.@@Vu MT, Martinis SA: A unique insert of leucyl-tRNA synthetase is required for aminoacylation and not amino acid editing. Biochemistry. 2007 May 1;46(17):5170-6. Epub 2007 Apr 4.@@Hsu JL, Rho SB, Vannella KM, Martinis SA: Functional divergence of a unique C-terminal domain of leucyl-tRNA synthetase to accommodate its splicing and aminoacylation roles. J Biol Chem. 2006 Aug 11;281(32):23075-82. Epub 2006 Jun 14.@@Lue SW, Kelley SO: A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylation. Biochemistry. 2007 Apr 17;46(15):4466-72. Epub 2007 Mar 23. |
| Groups | Investigational; Nutraceutical |
| Direct Classification | Leucine and derivatives |
| SMILES | CC(C)C[C@H](N)C(O)=O |
| Pathways | 3-Methylglutaconic Aciduria Type III; 3-Methylglutaconic Aciduria Type I; beta-Ketothiolase Deficiency; Demeclocycline Action Pathway; Josamycin Action Pathway; Gentamicin Action Pathway; Lincomycin Action Pathway; Isobutyryl-CoA Dehydrogenase Deficiency; Methacycline Action Pathway; Clarithromycin Action Pathway; Paromomycin Action Pathway; Minocycline Action Pathway; Lymecycline Action Pathway; 2-Methyl-3-hydroxybutryl-CoA Dehydrogenase Deficiency; 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency; Glutaminolysis and Cancer; Troleandomycin Action Pathway; Amikacin Action Pathway; Methylmalonic Aciduria; Oxytetracycline Action Pathway; Tetracycline Action Pathway; Spectinomycin Action Pathway; Doxycycline Action Pathway; Telithromycin Action Pathway; Roxithromycin Action Pathway; Tigecycline Action Pathway; Valine, Leucine, and Isoleucine Degradation; Arbekacin Action Pathway; Isovaleric Acidemia; Chloramphenicol Action Pathway |
| PharmGKB | PA450197 |
| ChEMBL | CHEMBL291962 |
