| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10010118 | HBV | ENSG00000151224.13 | protein_coding | MAT1A | No | No | 4143 | Q00266 |
| TVIS44033939 | HTLV-1 | ENSG00000151224.13 | protein_coding | MAT1A | No | No | 4143 | Q00266 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MAT1A |
|---|---|
| DrugBank ID | DB00118 |
| Drug Name | Ademetionine |
| Target ID | BE0000407 |
| UniProt ID | Q00266 |
| Regulation Type | cofactor |
| PubMed IDs | 11301045; 12060674; 12631701; 12660248; 12671891 |
| Citations | Carretero MV, Latasa MU, Garcia-Trevijano ER, Corrales FJ, Wagner C, Mato JM, Avila MA: Inhibition of liver methionine adenosyltransferase gene expression by 3-methylcolanthrene: protective effect of S-adenosylmethionine. Biochem Pharmacol. 2001 May 1;61(9):1119-28.@@Martinez-Chantar ML, Corrales FJ, Martinez-Cruz LA, Garcia-Trevijano ER, Huang ZZ, Chen L, Kanel G, Avila MA, Mato JM, Lu SC: Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. FASEB J. 2002 Aug;16(10):1292-4. Epub 2002 Jun 7.@@Santamaria E, Avila MA, Latasa MU, Rubio A, Martin-Duce A, Lu SC, Mato JM, Corrales FJ: Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3065-70. Epub 2003 Mar 11.@@Martinez-Chantar ML, Latasa MU, Varela-Rey M, Lu SC, Garcia-Trevijano ER, Mato JM, Avila MA: L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine. J Biol Chem. 2003 May 30;278(22):19885-90. Epub 2003 Mar 26.@@Martinez-Chantar ML, Garcia-Trevijano ER, Latasa MU, Martin-Duce A, Fortes P, Caballeria J, Avila MA, Mato JM: Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma. Gastroenterology. 2003 Apr;124(4):940-8. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | 5'-deoxy-5'-thionucleosides |
| SMILES | C[S+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N |
| Pathways | Phosphatidylcholine Biosynthesis PC(14:0/20:0); Phosphatidylcholine Biosynthesis PC(14:0/20:4(5Z,8Z,11Z,14Z)); Histidinemia; Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); Phosphatidylcholine Biosynthesis PC(14:0/20:5(5Z,8Z,11Z,14Z,17Z)); Phosphatidylcholine Biosynthesis PC(14:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); Phosphatidylcholine Biosynthesis PC(14:0/20:2(11Z,14Z)); Tyrosine Metabolism; Disulfiram Action Pathway; Hyperprolinemia Type II; Methylhistidine Metabolism; Phosphatidylcholine Biosynthesis PC(14:0/15:0); Mercaptopurine Action Pathway; L-Arginine:Glycine Amidinotransferase Deficiency; Tyrosinemia Type I; Betaine Metabolism; Catecholamine Biosynthesis; Phenytoin (Antiarrhythmic) Action Pathway; Glycine and Serine Metabolism; Carnitine Synthesis; Phosphatidylcholine Biosynthesis PC(14:0/20:1(11Z)); Phosphatidylcholine Biosynthesis PC(14:0/22:5(4Z,7Z,10Z,13Z,16Z)); Hyperprolinemia Type I; Phosphatidylcholine Biosynthesis PC(14:0/18:2(9Z,12Z)); Phosphatidylcholine Biosynthesis PC(14:0/14:0); Histidine Metabolism; Cystathionine beta-Synthase Deficiency; Phosphatidylcholine Biosynthesis PC(14:0/16:1(9Z)); Arginine and Proline Metabolism; Sarcosine Oncometabolite Pathway |
| PharmGKB | PA164754994 |
| ChEMBL | CHEMBL1088977 |
