| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30077740 | HIV | ENSG00000131844.17 | protein_coding | MCCC2 | No | No | 64087 | Q9HCC0 |
| TVIS30078573 | HIV | ENSG00000131844.17 | protein_coding | MCCC2 | No | No | 64087 | Q9HCC0 |
| TVIS30076673 | HIV | ENSG00000131844.17 | protein_coding | MCCC2 | No | No | 64087 | Q9HCC0 |
| TVIS30062400 | HIV | ENSG00000131844.17 | protein_coding | MCCC2 | No | No | 64087 | Q9HCC0 |
| TVIS30062401 | HIV | ENSG00000131844.17 | protein_coding | MCCC2 | No | No | 64087 | Q9HCC0 |
| TVIS20000752 | HPV | ENSG00000131844.17 | protein_coding | MCCC2 | No | No | 64087 | Q9HCC0 |
| TVIS44031722 | HTLV-1 | ENSG00000131844.17 | protein_coding | MCCC2 | No | No | 64087 | Q9HCC0 |
| TVIS44022489 | HTLV-1 | ENSG00000131844.17 | protein_coding | MCCC2 | No | No | 64087 | Q9HCC0 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MCCC2 |
|---|---|
| DrugBank ID | DB00121 |
| Drug Name | Biotin |
| Target ID | BE0000072 |
| UniProt ID | Q9HCC0 |
| Regulation Type | cofactor |
| PubMed IDs | 16707089; 17266990; 17254330; 17659996; 16772434 |
| Citations | Santoro N, Brtva T, Roest SV, Siegel K, Waldrop GL: A high-throughput screening assay for the carboxyltransferase subunit of acetyl-CoA carboxylase. Anal Biochem. 2006 Jul 1;354(1):70-7. Epub 2006 May 3.@@de Queiroz MS, Waldrop GL: Modeling and numerical simulation of biotin carboxylase kinetics: implications for half-sites reactivity. J Theor Biol. 2007 May 7;246(1):167-75. Epub 2006 Dec 28.@@Ludke A, Kramer R, Burkovski A, Schluesener D, Poetsch A: A proteomic study of Corynebacterium glutamicum AAA+ protease FtsH. BMC Microbiol. 2007 Jan 25;7:6.@@Jitrapakdee S, Surinya KH, Adina-Zada A, Polyak SW, Stojkoski C, Smyth R, Booker GW, Cleland WW, Attwood PV, Wallace JC: Conserved Glu40 and Glu433 of the biotin carboxylase domain of yeast pyruvate carboxylase I isoenzyme are essential for the association of tetramers. Int J Biochem Cell Biol. 2007;39(11):2120-34. Epub 2007 Jun 27.@@Hassan YI, Zempleni J: Epigenetic regulation of chromatin structure and gene function by biotin. J Nutr. 2006 Jul;136(7):1763-5. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | Biotin and derivatives |
| SMILES | [H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2 |
| Pathways | Mitochondrial Complex II Deficiency; 3-Methylglutaconic Aciduria Type III; 2-Ketoglutarate Dehydrogenase Complex Deficiency; 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency; Isovaleric Aciduria; Pyruvate Carboxylase Deficiency; Warburg Effect; Isobutyryl-CoA Dehydrogenase Deficiency; Biotin Metabolism; Fructose-1,6-diphosphatase Deficiency; Methylmalonic Aciduria Due to Cobalamin-Related Disorders; Propionic Acidemia; Transfer of Acetyl Groups into Mitochondria; Malonic Aciduria; 2-Hydroxyglutric Aciduria (D and L Form); 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I; Congenital Lactic Acidosis; 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency; Fumarase Deficiency; Succinic Semialdehyde Dehydrogenase Deficiency; Alanine Metabolism; Methylmalonic Aciduria; 3-Methylglutaconic Aciduria Type IV; Lactic Acidemia; Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease; Primary Hyperoxaluria Type I; Triosephosphate Isomerase; The Oncogenic Action of 2-Hydroxyglutarate; Valine, Leucine, and Isoleucine Degradation; Maple Syrup Urine Disease |
| PharmGKB | PA448625 |
| ChEMBL | CHEMBL857 |
