| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10041084 | HBV | ENSG00000111142.14 | protein_coding | METAP2 | No | No | 10988 | A0A140VJE3 F8VQZ7 P50579 |
| TVIS30033822 | HIV | ENSG00000111142.14 | protein_coding | METAP2 | No | No | 10988 | A0A140VJE3 F8VQZ7 P50579 |
| TVIS20050655 | HPV | ENSG00000111142.14 | protein_coding | METAP2 | No | No | 10988 | A0A140VJE3 F8VQZ7 P50579 |
| TVIS20050272 | HPV | ENSG00000111142.14 | protein_coding | METAP2 | No | No | 10988 | A0A140VJE3 F8VQZ7 P50579 |
| TVIS20050296 | HPV | ENSG00000111142.14 | protein_coding | METAP2 | No | No | 10988 | A0A140VJE3 F8VQZ7 P50579 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | METAP2 |
|---|---|
| DrugBank ID | DB00134 |
| Drug Name | Methionine |
| Target ID | BE0001534 |
| UniProt ID | P50579 |
| Regulation Type | product of |
| PubMed IDs | 16917013; 16789740; 16823043; 17114291; 16540317 |
| Citations | Upadhya R, Zhang HS, Weiss LM: System for expression of microsporidian methionine amino peptidase type 2 (MetAP2) in the yeast Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2006 Oct;50(10):3389-95. Epub 2006 Aug 17.@@Sheppard GS, Wang J, Kawai M, Fidanze SD, BaMaung NY, Erickson SA, Barnes DM, Tedrow JS, Kolaczkowski L, Vasudevan A, Park DC, Wang GT, Sanders WJ, Mantei RA, Palazzo F, Tucker-Garcia L, Lou P, Zhang Q, Park CH, Kim KH, Petros A, Olejniczak E, Nettesheim D, Hajduk P, Henkin J, Lesniewski R, Davidsen SK, Bell RL: Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding. J Med Chem. 2006 Jun 29;49(13):3832-49.@@Addlagatta A, Matthews BW: Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase. Protein Sci. 2006 Aug;15(8):1842-8. Epub 2006 Jul 5.@@Hu X, Addlagatta A, Lu J, Matthews BW, Liu JO: Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18148-53. Epub 2006 Nov 17.@@Nonato MC, Widom J, Clardy J: Human methionine aminopeptidase type 2 in complex with L- and D-methionine. Bioorg Med Chem Lett. 2006 May 15;16(10):2580-3. Epub 2006 Mar 15. |
| Groups | Approved; Nutraceutical |
| Direct Classification | Methionine and derivatives |
| SMILES | CSCC[C@H](N)C(O)=O |
| Pathways | Demeclocycline Action Pathway; Spermidine and Spermine Biosynthesis; Lincomycin Action Pathway; Gentamicin Action Pathway; Josamycin Action Pathway; Methionine Adenosyltransferase Deficiency; Methacycline Action Pathway; Non-Ketotic Hyperglycinemia; Clarithromycin Action Pathway; Betaine Metabolism; Paromomycin Action Pathway; Minocycline Action Pathway; Lymecycline Action Pathway; Glycine and Serine Metabolism; Troleandomycin Action Pathway; Amikacin Action Pathway; Oxytetracycline Action Pathway; Tetracycline Action Pathway; Methionine Metabolism; Spectinomycin Action Pathway; Doxycycline Action Pathway; Dihydropyrimidine Dehydrogenase Deficiency (DHPD); Cystathionine beta-Synthase Deficiency; Telithromycin Action Pathway; Roxithromycin Action Pathway; Tigecycline Action Pathway; Sarcosine Oncometabolite Pathway; Sarcosinemia; Arbekacin Action Pathway; Chloramphenicol Action Pathway |
| PharmGKB | PA450423 |
| ChEMBL | CHEMBL42336 |
