| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30061297 | HIV | ENSG00000151611.17 | protein_coding | MMAA | No | No | 166785 | Q8IVH4 |
| TVIS20025212 | HPV | ENSG00000151611.17 | protein_coding | MMAA | No | No | 166785 | Q8IVH4 |
| TVIS20016038 | HPV | ENSG00000151611.17 | protein_coding | MMAA | No | No | 166785 | Q8IVH4 |
| TVIS20016048 | HPV | ENSG00000151611.17 | protein_coding | MMAA | No | No | 166785 | Q8IVH4 |
| TVIS44006400 | HTLV-1 | ENSG00000151611.17 | protein_coding | MMAA | No | No | 166785 | Q8IVH4 |
| TVIS44033609 | HTLV-1 | ENSG00000151611.17 | protein_coding | MMAA | No | No | 166785 | Q8IVH4 |
| TVIS44028149 | HTLV-1 | ENSG00000151611.17 | protein_coding | MMAA | No | No | 166785 | Q8IVH4 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MMAA |
|---|---|
| DrugBank ID | DB00115 |
| Drug Name | Cyanocobalamin |
| Target ID | BE0000320 |
| UniProt ID | Q8IVH4 |
| Regulation Type | binder |
| PubMed IDs | 15523652; 16697227; 29862147; 19700356 |
| Citations | Lerner-Ellis JP, Dobson CM, Wai T, Watkins D, Tirone JC, Leclerc D, Dore C, Lepage P, Gravel RA, Rosenblatt DS: Mutations in the MMAA gene in patients with the cblA disorder of vitamin B12 metabolism. Hum Mutat. 2004 Dec;24(6):509-16.@@Dobson CM, Gradinger A, Longo N, Wu X, Leclerc D, Lerner-Ellis J, Lemieux M, Belair C, Watkins D, Rosenblatt DS, Gravel RA: Homozygous nonsense mutation in the MCEE gene and siRNA suppression of methylmalonyl-CoA epimerase expression: a novel cause of mild methylmalonic aciduria. Mol Genet Metab. 2006 Aug;88(4):327-33. Epub 2006 May 11.@@Zhou X, Cui Y, Han J: Methylmalonic acidemia: Current status and research priorities. Intractable Rare Dis Res. 2018 May;7(2):73-78. doi: 10.5582/irdr.2018.01026.@@Froese DS, Zhang J, Healy S, Gravel RA: Mechanism of vitamin B12-responsiveness in cblC methylmalonic aciduria with homocystinuria. Mol Genet Metab. 2009 Dec;98(4):338-43. doi: 10.1016/j.ymgme.2009.07.014. Epub 2009 Aug 3. |
| Groups | Approved; Nutraceutical |
| Direct Classification | Cobalamin derivatives |
| SMILES | C[C@H](CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)[C@H]2N=C1C(C)=C1/N=C(/C=C3N=C(C(C)=C4[C@@H](CCC(N)=O)[C@](C)(CC(N)=O)[C@@]2(C)N4[Co+]C#N)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)C(C)(C)[C@@H]1CCC(N)=O)OP([O-])(=O)O[C@@H]1[C@@H](CO)O[C@@H]([C@@H]1O)N1C=NC2=C1C=C(C)C(C)=C2 |
| Pathways | |
| PharmGKB | PA451892 |
| ChEMBL | CHEMBL2110563 |
