| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20007672 | HPV | ENSG00000262406.3 | protein_coding | MMP12 | No | No | 4321 | P39900 |
| TVIS20012760 | HPV | ENSG00000262406.3 | protein_coding | MMP12 | No | No | 4321 | P39900 |
| TVIS20015907 | HPV | ENSG00000262406.3 | protein_coding | MMP12 | No | No | 4321 | P39900 |
| TVIS20015965 | HPV | ENSG00000262406.3 | protein_coding | MMP12 | No | No | 4321 | P39900 |
| TVIS20015865 | HPV | ENSG00000262406.3 | protein_coding | MMP12 | No | No | 4321 | P39900 |
| TVIS20016346 | HPV | ENSG00000262406.3 | protein_coding | MMP12 | No | No | 4321 | P39900 |
| TVIS20049593 | HPV | ENSG00000262406.3 | protein_coding | MMP12 | No | No | 4321 | P39900 |
| TVIS20013121 | HPV | ENSG00000262406.3 | protein_coding | MMP12 | No | No | 4321 | P39900 |
| TVIS20021282 | HPV | ENSG00000262406.3 | protein_coding | MMP12 | No | No | 4321 | P39900 |
| TVIS20016344 | HPV | ENSG00000262406.3 | protein_coding | MMP12 | No | No | 4321 | P39900 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MMP12 |
|---|---|
| DrugBank ID | DB00551 |
| Drug Name | Acetohydroxamic acid |
| Target ID | BE0001198 |
| UniProt ID | P39900 |
| Regulation Type | inhibitor |
| PubMed IDs | 16899369; 15809432; 17269766; 16959356 |
| Citations | Mannino C, Nievo M, Machetti F, Papakyriakou A, Calderone V, Fragai M, Guarna A: Synthesis of bicyclic molecular scaffolds (BTAa): an investigation towards new selective MMP-12 inhibitors. Bioorg Med Chem. 2006 Nov 15;14(22):7392-403. Epub 2006 Aug 8.@@Bertini I, Calderone V, Cosenza M, Fragai M, Lee YM, Luchinat C, Mangani S, Terni B, Turano P: Conformational variability of matrix metalloproteinases: beyond a single 3D structure. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5334-9. Epub 2005 Apr 4.@@Bertini I, Calderone V, Fragai M, Giachetti A, Loconte M, Luchinat C, Maletta M, Nativi C, Yeo KJ: Exploring the subtleties of drug-receptor interactions: the case of matrix metalloproteinases. J Am Chem Soc. 2007 Mar 7;129(9):2466-75. Epub 2007 Feb 2.@@Fukuda M, Peppas NA, McGinity JW: Floating hot-melt extruded tablets for gastroretentive controlled drug release system. J Control Release. 2006 Oct 10;115(2):121-9. Epub 2006 Jul 21. |
| Groups | Approved |
| Direct Classification | Acetohydroxamic acids |
| SMILES | CC(=O)NO |
| Pathways | |
| PharmGKB | PA164749213 |
| ChEMBL | CHEMBL734 |
