| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10013808 | HBV | ENSG00000099810.21 | protein_coding | MTAP | No | Yes | 4507 | Q13126 |
| TVIS20008796 | HPV | ENSG00000099810.21 | protein_coding | MTAP | No | Yes | 4507 | Q13126 |
| TVIS20063595 | HPV | ENSG00000099810.21 | protein_coding | MTAP | No | Yes | 4507 | Q13126 |
| TVIS44028924 | HTLV-1 | ENSG00000099810.21 | protein_coding | MTAP | No | Yes | 4507 | Q13126 |
| TVIS44030714 | HTLV-1 | ENSG00000099810.21 | protein_coding | MTAP | No | Yes | 4507 | Q13126 |
| TVIS44036192 | HTLV-1 | ENSG00000099810.21 | protein_coding | MTAP | No | Yes | 4507 | Q13126 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | MTAP |
|---|---|
| DrugBank ID | DB00173 |
| Drug Name | Adenine |
| Target ID | BE0001128 |
| UniProt ID | Q13126 |
| Regulation Type | |
| PubMed IDs | 16631464; 17041099; 17090056 |
| Citations | Chow WA, Bedell V, Gaytan P, Borden E, Goldblum J, Hicks D, Slovak ML: Methylthioadenosine phosphorylase gene deletions are frequently detected by fluorescence in situ hybridization in conventional chondrosarcomas. Cancer Genet Cytogenet. 2006 Apr 15;166(2):95-100.@@Chattopadhyay S, Zhao R, Tsai E, Schramm VL, Goldman ID: The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity. Mol Cancer Ther. 2006 Oct;5(10):2549-55.@@Singh V, Schramm VL: Transition-state structure of human 5'-methylthioadenosine phosphorylase. J Am Chem Soc. 2006 Nov 15;128(45):14691-6. |
| Groups | Approved; Nutraceutical |
| Direct Classification | 6-aminopurines |
| SMILES | NC1=C2NC=NC2=NC=N1 |
| Pathways | Gout or Kelley-Seegmiller Syndrome; Purine Metabolism; Lesch-Nyhan Syndrome (LNS); Myoadenylate Deaminase Deficiency; Molybdenum Cofactor Deficiency; Adenine Phosphoribosyltransferase Deficiency (APRT); Mercaptopurine Action Pathway; Xanthinuria Type I; Azathioprine Action Pathway; AICA-Ribosiduria; Thioguanine Action Pathway; Mitochondrial DNA Depletion Syndrome; Adenosine Deaminase Deficiency; Xanthine Dehydrogenase Deficiency (Xanthinuria); Purine Nucleoside Phosphorylase Deficiency; Adenylosuccinate Lyase Deficiency; Xanthinuria Type II |
| PharmGKB | PA448048 |
| ChEMBL | CHEMBL226345 |
