| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10003246 | HBV | ENSG00000100714.18 | protein_coding | MTHFD1 | No | No | 4522 | P11586 |
| TVIS10001753 | HBV | ENSG00000100714.18 | protein_coding | MTHFD1 | No | No | 4522 | P11586 |
| TVIS10016088 | HBV | ENSG00000100714.18 | protein_coding | MTHFD1 | No | No | 4522 | P11586 |
| TVIS10033108 | HBV | ENSG00000100714.18 | protein_coding | MTHFD1 | No | No | 4522 | P11586 |
| TVIS10021980 | HBV | ENSG00000100714.18 | protein_coding | MTHFD1 | No | No | 4522 | P11586 |
| TVIS10027266 | HBV | ENSG00000100714.18 | protein_coding | MTHFD1 | No | No | 4522 | P11586 |
| TVIS10023544 | HBV | ENSG00000100714.18 | protein_coding | MTHFD1 | No | No | 4522 | P11586 |
| TVIS10027267 | HBV | ENSG00000100714.18 | protein_coding | MTHFD1 | No | No | 4522 | P11586 |
| TVIS10027268 | HBV | ENSG00000100714.18 | protein_coding | MTHFD1 | No | No | 4522 | P11586 |
| TVIS10050351 | HBV | ENSG00000100714.18 | protein_coding | MTHFD1 | No | No | 4522 | P11586 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MTHFD1 |
|---|---|
| DrugBank ID | DB00116 |
| Drug Name | Tetrahydrofolic acid |
| Target ID | BE0000617 |
| UniProt ID | P11586 |
| Regulation Type | cofactor |
| PubMed IDs | 11323021; 16171773; 17533396; 12949177; 12937168 |
| Citations | Akar N, Akar E, Ozel D, Deda G, Sipahi T: Common mutations at the homocysteine metabolism pathway and pediatric stroke. Thromb Res. 2001 Apr 15;102(2):115-20.@@Walkup AS, Appling DR: Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase. Arch Biochem Biophys. 2005 Oct 15;442(2):196-205. Epub 2005 Aug 30.@@Matakidou A, El Galta R, Rudd MF, Webb EL, Bridle H, Eisen T, Houlston RS: Prognostic significance of folate metabolism polymorphisms for lung cancer. Br J Cancer. 2007 Jul 16;97(2):247-52. Epub 2007 May 29.@@Salmassi TM, Leadbetter JR: Analysis of genes of tetrahydrofolate-dependent metabolism from cultivated spirochaetes and the gut community of the termite Zootermopsis angusticollis. Microbiology. 2003 Sep;149(Pt 9):2529-37.@@Prasannan P, Pike S, Peng K, Shane B, Appling DR: Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls. J Biol Chem. 2003 Oct 31;278(44):43178-87. Epub 2003 Aug 22. |
| Groups | Nutraceutical |
| Direct Classification | Glutamic acid and derivatives |
| SMILES | NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1 |
| Pathways | Histidinemia; Lesch-Nyhan Syndrome (LNS); Molybdenum Cofactor Deficiency; Azathioprine Action Pathway; AICA-Ribosiduria; Purine Nucleoside Phosphorylase Deficiency; Methionine Adenosyltransferase Deficiency; Folate Malabsorption, Hereditary; Adenine Phosphoribosyltransferase Deficiency (APRT); Thioguanine Action Pathway; Mercaptopurine Action Pathway; Non-Ketotic Hyperglycinemia; Methotrexate Action Pathway; Betaine Metabolism; S-Adenosylhomocysteine (SAH) Hydrolase Deficiency; Glycine and Serine Metabolism; Adenosine Deaminase Deficiency; Xanthinuria Type II; Methionine Metabolism; Dihydropyrimidine Dehydrogenase Deficiency (DHPD); Histidine Metabolism; Cystathionine beta-Synthase Deficiency; Folate Metabolism; Sarcosine Oncometabolite Pathway; Sarcosinemia; Methylenetetrahydrofolate Reductase Deficiency (MTHFRD); Purine Metabolism; Gout or Kelley-Seegmiller Syndrome; Adenylosuccinate Lyase Deficiency; Ammonia Recycling |
| PharmGKB | PA164745110 |
| ChEMBL | CHEMBL2021342 |
