| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30074144 | HIV | ENSG00000124275.15 | protein_coding | MTRR | No | No | 4552 | Q9UBK8 |
| TVIS30061858 | HIV | ENSG00000124275.15 | protein_coding | MTRR | No | No | 4552 | Q9UBK8 |
| TVIS30061859 | HIV | ENSG00000124275.15 | protein_coding | MTRR | No | No | 4552 | Q9UBK8 |
| TVIS30061860 | HIV | ENSG00000124275.15 | protein_coding | MTRR | No | No | 4552 | Q9UBK8 |
| TVIS30061861 | HIV | ENSG00000124275.15 | protein_coding | MTRR | No | No | 4552 | Q9UBK8 |
| TVIS20068237 | HPV | ENSG00000124275.15 | protein_coding | MTRR | No | No | 4552 | Q9UBK8 |
| TVIS44030127 | HTLV-1 | ENSG00000124275.15 | protein_coding | MTRR | No | No | 4552 | Q9UBK8 |
| TVIS44014688 | HTLV-1 | ENSG00000124275.15 | protein_coding | MTRR | No | No | 4552 | Q9UBK8 |
| TVIS44003968 | HTLV-1 | ENSG00000124275.15 | protein_coding | MTRR | No | No | 4552 | Q9UBK8 |
| TVIS44050471 | HTLV-1 | ENSG00000124275.15 | protein_coding | MTRR | No | No | 4552 | Q9UBK8 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MTRR |
|---|---|
| DrugBank ID | DB00115 |
| Drug Name | Cyanocobalamin |
| Target ID | BE0000763 |
| UniProt ID | Q9UBK8 |
| Regulation Type | cofactor |
| PubMed IDs | 15979034; 15612980; 17611986 |
| Citations | O'Leary VB, Mills JL, Pangilinan F, Kirke PN, Cox C, Conley M, Weiler A, Peng K, Shane B, Scott JM, Parle-McDermott A, Molloy AM, Brody LC: Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association. Mol Genet Metab. 2005 Jul;85(3):220-7. Epub 2005 Mar 17.@@Miriuka SG, Langman LJ, Evrovski J, Miner SE, D'Mello N, Delgado DH, Wong BY, Ross HJ, Cole DE: Genetic polymorphisms predisposing to hyperhomocysteinemia in cardiac transplant patients. Transpl Int. 2005 Jan;18(1):29-35.@@Berkun Y, Abou Atta I, Rubinow A, Orbach H, Levartovsky D, Aamar S, Arbel O, Dresner-Pollak R, Friedman G, Ben-Yehuda A: 2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis. J Rheumatol. 2007 Aug;34(8):1664-9. Epub 2007 Jul 1. |
| Groups | Approved; Nutraceutical |
| Direct Classification | Cobalamin derivatives |
| SMILES | C[C@H](CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)[C@H]2N=C1C(C)=C1/N=C(/C=C3N=C(C(C)=C4[C@@H](CCC(N)=O)[C@](C)(CC(N)=O)[C@@]2(C)N4[Co+]C#N)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)C(C)(C)[C@@H]1CCC(N)=O)OP([O-])(=O)O[C@@H]1[C@@H](CO)O[C@@H]([C@@H]1O)N1C=NC2=C1C=C(C)C(C)=C2 |
| Pathways | |
| PharmGKB | PA451892 |
| ChEMBL | CHEMBL2110563 |
