| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10027478 | HBV | ENSG00000103174.13 | protein_coding | NAGPA | No | No | 51172 | Q9UK23 |
| TVIS10016443 | HBV | ENSG00000103174.13 | protein_coding | NAGPA | No | No | 51172 | Q9UK23 |
| TVIS44036002 | HTLV-1 | ENSG00000103174.13 | protein_coding | NAGPA | No | No | 51172 | Q9UK23 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | NAGPA |
|---|---|
| DrugBank ID | DB00141 |
| Drug Name | N-Acetylglucosamine |
| Target ID | BE0002266 |
| UniProt ID | Q9UK23 |
| Regulation Type | |
| PubMed IDs | 17139284; 17016423; 8294420; 17927214; 9722550 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Mullis KG, Huynh M, Kornfeld RH: Purification and kinetic parameters of bovine liver N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. J Biol Chem. 1994 Jan 21;269(3):1718-26.@@Chavez CA, Bohnsack RN, Kudo M, Gotschall RR, Canfield WM, Dahms NM: Domain 5 of the cation-independent mannose 6-phosphate receptor preferentially binds phosphodiesters (mannose 6-phosphate N-acetylglucosamine ester). Biochemistry. 2007 Nov 6;46(44):12604-17. Epub 2007 Oct 10.@@Kornfeld R, Bao M, Brewer K, Noll C, Canfield WM: Purification and multimeric structure of bovine N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. J Biol Chem. 1998 Sep 4;273(36):23203-10. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | Hexoses |
| SMILES | [H]C(=O)[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@H](O)CO |
| Pathways | G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease; Sialuria or French Type Sialuria; Tay-Sachs Disease; Salla Disease/Infantile Sialic Acid Storage Disease; Amino Sugar Metabolism |
| PharmGKB | PA164752287 |
| ChEMBL | CHEMBL4303483 |
