| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30062256 | HIV | ENSG00000164258.12 | protein_coding | NDUFS4 | No | No | 4724 | A0A0S2Z433 O43181 |
| TVIS30062257 | HIV | ENSG00000164258.12 | protein_coding | NDUFS4 | No | No | 4724 | A0A0S2Z433 O43181 |
| TVIS30062258 | HIV | ENSG00000164258.12 | protein_coding | NDUFS4 | No | No | 4724 | A0A0S2Z433 O43181 |
| TVIS20012087 | HPV | ENSG00000164258.12 | protein_coding | NDUFS4 | No | No | 4724 | A0A0S2Z433 O43181 |
| TVIS20009866 | HPV | ENSG00000164258.12 | protein_coding | NDUFS4 | No | No | 4724 | A0A0S2Z433 O43181 |
| TVIS20014849 | HPV | ENSG00000164258.12 | protein_coding | NDUFS4 | No | No | 4724 | A0A0S2Z433 O43181 |
| TVIS20014850 | HPV | ENSG00000164258.12 | protein_coding | NDUFS4 | No | No | 4724 | A0A0S2Z433 O43181 |
| TVIS20014851 | HPV | ENSG00000164258.12 | protein_coding | NDUFS4 | No | No | 4724 | A0A0S2Z433 O43181 |
| TVIS44019574 | HTLV-1 | ENSG00000164258.12 | protein_coding | NDUFS4 | No | No | 4724 | A0A0S2Z433 O43181 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | NDUFS4 |
|---|---|
| DrugBank ID | DB00157 |
| Drug Name | NADH |
| Target ID | BE0000500 |
| UniProt ID | O43181 |
| Regulation Type | |
| PubMed IDs | 17139284; 17016423; 11860175; 11181577; 11864782 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Papa S, Sardanelli AM, Scacco S, Petruzzella V, Technikova-Dobrova Z, Vergari R, Signorile A: The NADH: ubiquinone oxidoreductase (complex I) of the mammalian respiratory chain and the cAMP cascade. J Bioenerg Biomembr. 2002 Feb;34(1):1-10.@@Petruzzella V, Vergari R, Puzziferri I, Boffoli D, Lamantea E, Zeviani M, Papa S: A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome. Hum Mol Genet. 2001 Mar 1;10(5):529-35.@@Raha S, Myint AT, Johnstone L, Robinson BH: Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase. Free Radic Biol Med. 2002 Mar 1;32(5):421-30. |
| Groups | Approved; Nutraceutical |
| Direct Classification | (5'->5')-dinucleotides |
| SMILES | NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O |
| Pathways | Ethylmalonic Encephalopathy; 3-Methylglutaconic Aciduria Type III; Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency); Caffeine Metabolism; Fructose and Mannose Degradation; Isovaleric Aciduria; Lysine Degradation; Methylmalonic Aciduria Due to Cobalamin-Related Disorders; Glycerol Phosphate Shuttle; Zellweger Syndrome; Propionic Acidemia; Glycolysis; Xanthine Dehydrogenase Deficiency (Xanthinuria); S-Adenosylhomocysteine (SAH) Hydrolase Deficiency; Tryptophan Metabolism; Glutaric Aciduria Type I; 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I; Glycine N-Methyltransferase Deficiency; Dimethylglycine Dehydrogenase Deficiency; Androgen and Estrogen Metabolism; Nucleotide Sugars Metabolism; 3-Methylglutaconic Aciduria Type IV; Dihydropyrimidine Dehydrogenase Deficiency (DHPD); Malate-Aspartate Shuttle; Folate Metabolism; Valine, Leucine, and Isoleucine Degradation; Maple Syrup Urine Disease; Glycerol Kinase Deficiency; Adenylosuccinate Lyase Deficiency; Cysteine Metabolism |
| PharmGKB | PA164755085 |
| ChEMBL | CHEMBL1234616 |
