Target Gene Table
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS44044767HTLV-1ENSG00000128050.9protein_codingPAICSNoNo10606P22234
TVIS44044860HTLV-1ENSG00000128050.9protein_codingPAICSNoNo10606P22234
TVIS44044859HTLV-1ENSG00000128050.9protein_codingPAICSNoNo10606P22234
TCGA Plot Options
Drug Information
GenePAICS
DrugBank IDDB00128
Drug NameAspartic acid
Target IDBE0002225
UniProt IDP22234
Regulation Typesubstrate
PubMed IDs15641804; 1842094; 4772278
CitationsNelson SW, Binkowski DJ, Honzatko RB, Fromm HJ: Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase. Biochemistry. 2005 Jan 18;44(2):766-74. doi: 10.1021/bi048191w.@@Buchanan JG, Wightman RH: Synthesis of nucleosides as potential inhibitors of purine biosynthesis. Nucleic Acids Symp Ser. 1991;(25):53-4. doi: 10.1002/chin.199031303.@@Patey CA, Shaw G: Purification and properties of an enzyme duet, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthetase, involved in the biosynthesis of purine nucleotides de novo. Biochem J. 1973 Nov;135(3):543-5. doi: 10.1042/bj1350543.
GroupsApproved; Nutraceutical
Direct ClassificationAspartic acid and derivatives
SMILESN[C@@H](CC(O)=O)C(O)=O
PathwaysLesch-Nyhan Syndrome (LNS); Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); Xanthinuria Type I; Hyperornithinemia with Gyrate Atrophy (HOGA); Purine Nucleoside Phosphorylase Deficiency; Carnosinuria, Carnosinemia; Tyrosine Metabolism; Disulfiram Action Pathway; Hyperprolinemia Type II; Glutamate Metabolism; Adenine Phosphoribosyltransferase Deficiency (APRT); Mercaptopurine Action Pathway; Argininosuccinic Aciduria; L-Arginine:Glycine Amidinotransferase Deficiency; Xanthine Dehydrogenase Deficiency (Xanthinuria); Tyrosinemia Type I; Hyperinsulinism-Hyperammonemia Syndrome; Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency); Mitochondrial DNA Depletion Syndrome; Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency; Carbamoyl Phosphate Synthetase Deficiency; Hyperprolinemia Type I; Myoadenylate Deaminase Deficiency; Homocarnosinosis; Malate-Aspartate Shuttle; Arginine and Proline Metabolism; Purine Metabolism; Gout or Kelley-Seegmiller Syndrome; Adenylosuccinate Lyase Deficiency; Ammonia Recycling
PharmGKBPA448494
ChEMBLCHEMBL274323