VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
---|---|---|---|---|---|---|---|---|
TVIS44044767 | HTLV-1 | ENSG00000128050.9 | protein_coding | PAICS | No | No | 10606 | P22234 |
TVIS44044860 | HTLV-1 | ENSG00000128050.9 | protein_coding | PAICS | No | No | 10606 | P22234 |
TVIS44044859 | HTLV-1 | ENSG00000128050.9 | protein_coding | PAICS | No | No | 10606 | P22234 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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Gene | PAICS |
---|---|
DrugBank ID | DB00128 |
Drug Name | Aspartic acid |
Target ID | BE0002225 |
UniProt ID | P22234 |
Regulation Type | substrate |
PubMed IDs | 15641804; 1842094; 4772278 |
Citations | Nelson SW, Binkowski DJ, Honzatko RB, Fromm HJ: Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase. Biochemistry. 2005 Jan 18;44(2):766-74. doi: 10.1021/bi048191w.@@Buchanan JG, Wightman RH: Synthesis of nucleosides as potential inhibitors of purine biosynthesis. Nucleic Acids Symp Ser. 1991;(25):53-4. doi: 10.1002/chin.199031303.@@Patey CA, Shaw G: Purification and properties of an enzyme duet, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthetase, involved in the biosynthesis of purine nucleotides de novo. Biochem J. 1973 Nov;135(3):543-5. doi: 10.1042/bj1350543. |
Groups | Approved; Nutraceutical |
Direct Classification | Aspartic acid and derivatives |
SMILES | N[C@@H](CC(O)=O)C(O)=O |
Pathways | Lesch-Nyhan Syndrome (LNS); Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); Xanthinuria Type I; Hyperornithinemia with Gyrate Atrophy (HOGA); Purine Nucleoside Phosphorylase Deficiency; Carnosinuria, Carnosinemia; Tyrosine Metabolism; Disulfiram Action Pathway; Hyperprolinemia Type II; Glutamate Metabolism; Adenine Phosphoribosyltransferase Deficiency (APRT); Mercaptopurine Action Pathway; Argininosuccinic Aciduria; L-Arginine:Glycine Amidinotransferase Deficiency; Xanthine Dehydrogenase Deficiency (Xanthinuria); Tyrosinemia Type I; Hyperinsulinism-Hyperammonemia Syndrome; Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency); Mitochondrial DNA Depletion Syndrome; Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency; Carbamoyl Phosphate Synthetase Deficiency; Hyperprolinemia Type I; Myoadenylate Deaminase Deficiency; Homocarnosinosis; Malate-Aspartate Shuttle; Arginine and Proline Metabolism; Purine Metabolism; Gout or Kelley-Seegmiller Syndrome; Adenylosuccinate Lyase Deficiency; Ammonia Recycling |
PharmGKB | PA448494 |
ChEMBL | CHEMBL274323 |