| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44026689 | HTLV-1 | ENSG00000110218.9 | protein_coding | PANX1 | No | No | 24145 | Q96RD7 |
| TVIS44023327 | HTLV-1 | ENSG00000110218.9 | protein_coding | PANX1 | No | No | 24145 | Q96RD7 |
| TVIS44010425 | HTLV-1 | ENSG00000110218.9 | protein_coding | PANX1 | No | No | 24145 | Q96RD7 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PANX1 |
|---|---|
| DrugBank ID | DB01032 |
| Drug Name | Probenecid |
| Target ID | BE0003719 |
| UniProt ID | Q96RD7 |
| Regulation Type | antagonist |
| PubMed IDs | 18596212; 19213873; 19023039; 19416975; 19780818 |
| Citations | Silverman W, Locovei S, Dahl G: Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol. 2008 Sep;295(3):C761-7. doi: 10.1152/ajpcell.00227.2008. Epub 2008 Jul 2.@@Ransford GA, Fregien N, Qiu F, Dahl G, Conner GE, Salathe M: Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol. 2009 Nov;41(5):525-34. doi: 10.1165/rcmb.2008-0367OC. Epub 2009 Feb 12.@@Ma W, Hui H, Pelegrin P, Surprenant A: Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J Pharmacol Exp Ther. 2009 Feb;328(2):409-18. doi: 10.1124/jpet.108.146365. Epub 2008 Nov 20.@@Silverman WR, de Rivero Vaccari JP, Locovei S, Qiu F, Carlsson SK, Scemes E, Keane RW, Dahl G: The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem. 2009 Jul 3;284(27):18143-51. doi: 10.1074/jbc.M109.004804. Epub 2009 May 5.@@Bunse S, Locovei S, Schmidt M, Qiu F, Zoidl G, Dahl G, Dermietzel R: The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials. FEBS J. 2009 Nov;276(21):6258-70. doi: 10.1111/j.1742-4658.2009.07334.x. Epub 2009 Sep 24. |
| Groups | Approved; Investigational |
| Direct Classification | Benzenesulfonamides |
| SMILES | CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(O)=O |
| Pathways | |
| PharmGKB | PA451106 |
| ChEMBL | CHEMBL897 |
