| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30088922 | HIV | ENSG00000011422.12 | protein_coding | PLAUR | No | No | 5329 | M0R1I2 Q03405 |
| TVIS44047929 | HTLV-1 | ENSG00000011422.12 | protein_coding | PLAUR | No | No | 5329 | M0R1I2 Q03405 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PLAUR |
|---|---|
| DrugBank ID | DB00013 |
| Drug Name | Urokinase |
| Target ID | BE0000717 |
| UniProt ID | Q03405 |
| Regulation Type | inducer |
| PubMed IDs | 12615913; 12817472; 14679304; 14688365; 14720519; 17327908 |
| Citations | Czekay RP, Aertgeerts K, Curriden SA, Loskutoff DJ: Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins. J Cell Biol. 2003 Mar 3;160(5):781-91.@@Fuchs T, Allgayer H: Transcriptional regulation of the urokinase receptor (u-PAR)--a central molecule of invasion and metastasis. Biol Chem. 2003 May;384(5):755-61.@@Kanse SM, Chavakis T, Al-Fakhri N, Hersemeyer K, Monard D, Preissner KT: Reciprocal regulation of urokinase receptor (CD87)-mediated cell adhesion by plasminogen activator inhibitor-1 and protease nexin-1. J Cell Sci. 2004 Jan 26;117(Pt 3):477-85. Epub 2003 Dec 16.@@Beaufort N, Leduc D, Rousselle JC, Magdolen V, Luther T, Namane A, Chignard M, Pidard D: Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G. J Immunol. 2004 Jan 1;172(1):540-9.@@Guerrero J, Santibanez JF, Gonzalez A, Martinez J: EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases. Exp Cell Res. 2004 Jan 1;292(1):201-8.@@Gutova M, Najbauer J, Gevorgyan A, Metz MZ, Weng Y, Shih CC, Aboody KS: Identification of uPAR-positive chemoresistant cells in small cell lung cancer. PLoS One. 2007 Feb 28;2(2):e243. |
| Groups | Approved; Investigational; Withdrawn |
| Direct Classification | Peptides |
| SMILES | |
| Pathways | Urokinase Action Pathway |
| PharmGKB | PA451836 |
| ChEMBL | CHEMBL1201420 |
