| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10034061 | HBV | ENSG00000177084.19 | protein_coding | POLE | No | Yes | 5426 | Q07864 |
| TVIS30004477 | HIV | ENSG00000177084.19 | protein_coding | POLE | No | Yes | 5426 | Q07864 |
| TVIS30010288 | HIV | ENSG00000177084.19 | protein_coding | POLE | No | Yes | 5426 | Q07864 |
| TVIS30006298 | HIV | ENSG00000177084.19 | protein_coding | POLE | No | Yes | 5426 | Q07864 |
| TVIS30088285 | HIV | ENSG00000177084.19 | protein_coding | POLE | No | Yes | 5426 | Q07864 |
| TVIS30034626 | HIV | ENSG00000177084.19 | protein_coding | POLE | No | Yes | 5426 | Q07864 |
| TVIS30034627 | HIV | ENSG00000177084.19 | protein_coding | POLE | No | Yes | 5426 | Q07864 |
| TVIS30034628 | HIV | ENSG00000177084.19 | protein_coding | POLE | No | Yes | 5426 | Q07864 |
| TVIS30034629 | HIV | ENSG00000177084.19 | protein_coding | POLE | No | Yes | 5426 | Q07864 |
| TVIS30034630 | HIV | ENSG00000177084.19 | protein_coding | POLE | No | Yes | 5426 | Q07864 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | POLE |
|---|---|
| DrugBank ID | DB00242 |
| Drug Name | Cladribine |
| Target ID | BE0003614 |
| UniProt ID | Q07864 |
| Regulation Type | inhibitor |
| PubMed IDs | 19576186 |
| Citations | Zhenchuk A, Lotfi K, Juliusson G, Albertioni F: Mechanisms of anti-cancer action and pharmacology of clofarabine. Biochem Pharmacol. 2009 Dec 1;78(11):1351-9. doi: 10.1016/j.bcp.2009.06.094. Epub 2009 Jul 1. |
| Groups | Approved; Investigational |
| Direct Classification | Purine 2'-deoxyribonucleosides |
| SMILES | NC1=C2N=CN([C@H]3C[C@H](O)[C@@H](CO)O3)C2=NC(Cl)=N1 |
| Pathways | |
| PharmGKB | PA449027 |
| ChEMBL | CHEMBL1619 |
