| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30013537 | HIV | ENSG00000196262.15 | protein_coding | PPIA | No | No | 5478 | P62937 |
| TVIS30067103 | HIV | ENSG00000196262.15 | protein_coding | PPIA | No | No | 5478 | P62937 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PPIA |
|---|---|
| DrugBank ID | DB00091 |
| Drug Name | Cyclosporine |
| Target ID | BE0001014 |
| UniProt ID | P62937 |
| Regulation Type | inhibitor |
| PubMed IDs | 17461417; 17609268; 20637127; 20368803 |
| Citations | Redell JB, Zhao J, Dash PK: Acutely increased cyclophilin a expression after brain injury: a role in blood-brain barrier function and tissue preservation. J Neurosci Res. 2007 Jul;85(9):1980-8.@@Schaller T, Ylinen LM, Webb BL, Singh S, Towers GJ: Fusion of cyclophilin A to Fv1 enables cyclosporine-sensitive restriction of human and feline immunodeficiency viruses. J Virol. 2007 Sep;81(18):10055-63. Epub 2007 Jul 3.@@Lee J, Kim SS: Current implications of cyclophilins in human cancers. J Exp Clin Cancer Res. 2010 Jul 19;29:97. doi: 10.1186/1756-9966-29-97.@@Stegmann CM, Luhrmann R, Wahl MC: The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. PLoS One. 2010 Apr 2;5(4):e10013. doi: 10.1371/journal.pone.0010013. |
| Groups | Approved; Investigational; Vet_approved |
| Direct Classification | Cyclosporins |
| SMILES | CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)CC=CC)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C |
| Pathways | |
| PharmGKB | PA449167 |
| ChEMBL | CHEMBL160 |
