| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30001279 | HIV | ENSG00000080815.20 | protein_coding | PSEN1 | No | No | 5663 | A0A024R6A3 A0A0S2Z4D2 P49768 |
| TVIS30011914 | HIV | ENSG00000080815.20 | protein_coding | PSEN1 | No | No | 5663 | A0A024R6A3 A0A0S2Z4D2 P49768 |
| TVIS30010328 | HIV | ENSG00000080815.20 | protein_coding | PSEN1 | No | No | 5663 | A0A024R6A3 A0A0S2Z4D2 P49768 |
| TVIS30036810 | HIV | ENSG00000080815.20 | protein_coding | PSEN1 | No | No | 5663 | A0A024R6A3 A0A0S2Z4D2 P49768 |
| TVIS30036811 | HIV | ENSG00000080815.20 | protein_coding | PSEN1 | No | No | 5663 | A0A024R6A3 A0A0S2Z4D2 P49768 |
| TVIS30036812 | HIV | ENSG00000080815.20 | protein_coding | PSEN1 | No | No | 5663 | A0A024R6A3 A0A0S2Z4D2 P49768 |
| TVIS30036813 | HIV | ENSG00000080815.20 | protein_coding | PSEN1 | No | No | 5663 | A0A024R6A3 A0A0S2Z4D2 P49768 |
| TVIS30036814 | HIV | ENSG00000080815.20 | protein_coding | PSEN1 | No | No | 5663 | A0A024R6A3 A0A0S2Z4D2 P49768 |
| TVIS30036815 | HIV | ENSG00000080815.20 | protein_coding | PSEN1 | No | No | 5663 | A0A024R6A3 A0A0S2Z4D2 P49768 |
| TVIS30036816 | HIV | ENSG00000080815.20 | protein_coding | PSEN1 | No | No | 5663 | A0A024R6A3 A0A0S2Z4D2 P49768 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PSEN1 |
|---|---|
| DrugBank ID | DB12005 |
| Drug Name | Nirogacestat |
| Target ID | BE0010960 |
| UniProt ID | P49768 |
| Regulation Type | inhibitor |
| PubMed IDs | 32607444; 31198028; 33284507 |
| Citations | Bhattarai A, Devkota S, Bhattarai S, Wolfe MS, Miao Y: Mechanisms of gamma-Secretase Activation and Substrate Processing. ACS Cent Sci. 2020 Jun 24;6(6):969-983. doi: 10.1021/acscentsci.0c00296. Epub 2020 Jun 4.@@Wolfe MS: Structure and Function of the gamma-Secretase Complex. Biochemistry. 2019 Jul 9;58(27):2953-2966. doi: 10.1021/acs.biochem.9b00401. Epub 2019 Jun 25.@@McCaw TR, Inga E, Chen H, Jaskula-Sztul R, Dudeja V, Bibb JA, Ren B, Rose JB: Gamma Secretase Inhibitors in Cancer: A Current Perspective on Clinical Performance. Oncologist. 2021 Apr;26(4):e608-e621. doi: 10.1002/onco.13627. Epub 2021 Jan 2. |
| Groups | Approved; Investigational |
| Direct Classification | Alpha amino acid amides |
| SMILES | CCC[C@H](N[C@H]1CCC2=CC(F)=CC(F)=C2C1)C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL1770916 |
