| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30079475 | HIV | ENSG00000124212.6 | protein_coding | PTGIS | No | No | 5740 | Q16647 |
| TVIS20001251 | HPV | ENSG00000124212.6 | protein_coding | PTGIS | No | No | 5740 | Q16647 |
| TVIS44021396 | HTLV-1 | ENSG00000124212.6 | protein_coding | PTGIS | No | No | 5740 | Q16647 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PTGIS |
|---|---|
| DrugBank ID | DB00812 |
| Drug Name | Phenylbutazone |
| Target ID | BE0000117 |
| UniProt ID | Q16647 |
| Regulation Type | inhibitor |
| PubMed IDs | 17139284; 17016423; 3917545; 6434940; 3517382 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Reed GA, Griffin IO, Eling TE: Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol Pharmacol. 1985 Jan;27(1):109-14.@@Marnett LJ, Siedlik PH, Ochs RC, Pagels WR, Das M, Honn KV, Warnock RH, Tainer BE, Eling TE: Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom. Mol Pharmacol. 1984 Sep;26(2):328-35.@@Tobin T, Chay S, Kamerling S, Woods WE, Weckman TJ, Blake JW, Lees P: Phenylbutazone in the horse: a review. J Vet Pharmacol Ther. 1986 Mar;9(1):1-25. |
| Groups | Approved; Vet_approved |
| Direct Classification | Benzene and substituted derivatives |
| SMILES | CCCCC1C(=O)N(N(C1=O)C1=CC=CC=C1)C1=CC=CC=C1 |
| Pathways | Phenylbutazone Action Pathway |
| PharmGKB | PA450932 |
| ChEMBL | CHEMBL101 |
