| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20051534 | HPV | ENSG00000139988.10 | protein_coding | RDH12 | No | No | 145226 | A0A0S2Z613 Q96NR8 |
| TVIS44012376 | HTLV-1 | ENSG00000139988.10 | protein_coding | RDH12 | No | No | 145226 | A0A0S2Z613 Q96NR8 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | RDH12 |
|---|---|
| DrugBank ID | DB00162 |
| Drug Name | Vitamin A |
| Target ID | BE0000726 |
| UniProt ID | Q96NR8 |
| Regulation Type | substrate |
| PubMed IDs | 17032653; 16269441; 17512723 |
| Citations | Maeda A, Maeda T, Imanishi Y, Sun W, Jastrzebska B, Hatala DA, Winkens HJ, Hofmann KP, Janssen JJ, Baehr W, Driessen CA, Palczewski K: Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. J Biol Chem. 2006 Dec 8;281(49):37697-704. Epub 2006 Oct 10.@@Thompson DA, Janecke AR, Lange J, Feathers KL, Hubner CA, McHenry CL, Stockton DW, Rammesmayer G, Lupski JR, Antinolo G, Ayuso C, Baiget M, Gouras P, Heckenlively JR, den Hollander A, Jacobson SG, Lewis RA, Sieving PA, Wissinger B, Yzer S, Zrenner E, Utermann G, Gal A: Retinal degeneration associated with RDH12 mutations results from decreased 11-cis retinal synthesis due to disruption of the visual cycle. Hum Mol Genet. 2005 Dec 15;14(24):3865-75. Epub 2005 Nov 3.@@Keller B, Adamski J: RDH12, a retinol dehydrogenase causing Leber's congenital amaurosis, is also involved in steroid metabolism. J Steroid Biochem Mol Biol. 2007 May;104(3-5):190-4. Epub 2007 Mar 23. |
| Groups | Approved; Nutraceutical; Vet_approved |
| Direct Classification | Retinoids |
| SMILES | CC(=C/CO)C=CC=C(/C)C=CC1=C(C)CCCC1(C)C |
| Pathways | Retinol Metabolism; Vitamin A Deficiency |
| PharmGKB | PA451884 |
| ChEMBL | CHEMBL986 |
