| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30084527 | HIV | ENSG00000143839.15 | protein_coding | REN | No | No | 5972 | P00797 |
| TVIS20008388 | HPV | ENSG00000143839.15 | protein_coding | REN | No | No | 5972 | P00797 |
| TVIS44024466 | HTLV-1 | ENSG00000143839.15 | protein_coding | REN | No | No | 5972 | P00797 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | REN |
|---|---|
| DrugBank ID | DB00212 |
| Drug Name | Remikiren |
| Target ID | BE0000270 |
| UniProt ID | P00797 |
| Regulation Type | inhibitor |
| PubMed IDs | 10583449; 7769797; 7994817; 8206619; 8319997; 11752352 |
| Citations | van Paassen P, Navis GJ, De Jong PE, De Zeeuw D: Pretreatment renal vascular tone predicts the effect of specific renin inhibition on natriuresis in essential hypertension. Eur J Clin Invest. 1999 Dec;29(12):1019-26.@@MacFadyen RJ, Jones CR, Doig JK, Birnbock H, Reid JL: Responses to an orally active renin inhibitor, remikiren (Ro 42-5892), after controlled salt depletion in humans. J Cardiovasc Pharmacol. 1995 Mar;25(3):347-53.@@Kiowski W, Beermann J, Rickenbacher P, Haemmerli R, Thomas M, Burkart F, Meinertz T: Angiotensinergic versus nonangiotensinergic hemodynamic effects of converting enzyme inhibition in patients with chronic heart failure. Assessment by acute renin and converting enzyme inhibition. Circulation. 1994 Dec;90(6):2748-56.@@Hilgers KF, Fischli W, Veelken R, Mann JF: Vascular renin in the guinea pig. Suppression by the renin inhibitor remikiren. Hypertension. 1994 Jun;23(6 Pt 2):861-4.@@Clozel JP, Fischli W: Comparative effects of three different potent renin inhibitors in primates. Hypertension. 1993 Jul;22(1):9-17.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Experimental |
| Direct Classification | Histidine and derivatives |
| SMILES | CC(C)(C)S(=O)(=O)C[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C1CC1 |
| Pathways | |
| PharmGKB | PA164774779 |
| ChEMBL | CHEMBL31601 |
