| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30004395 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
| TVIS30005737 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
| TVIS30028946 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
| TVIS30028947 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
| TVIS30028948 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
| TVIS30028949 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
| TVIS30028950 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
| TVIS30028951 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
| TVIS30028952 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | RRM1 |
|---|---|
| DrugBank ID | DB00242 |
| Drug Name | Cladribine |
| Target ID | BE0000325 |
| UniProt ID | P23921 |
| Regulation Type | inhibitor |
| PubMed IDs | 19715446; 17852710; 19576186; 16316309; 9923554 |
| Citations | Sampat K, Kantarjian H, Borthakur G: Clofarabine: emerging role in leukemias. Expert Opin Investig Drugs. 2009 Oct;18(10):1559-64. doi: 10.1517/13543780903173222.@@Kantarjian HM, Jeha S, Gandhi V, Wess M, Faderl S: Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30.@@Zhenchuk A, Lotfi K, Juliusson G, Albertioni F: Mechanisms of anti-cancer action and pharmacology of clofarabine. Biochem Pharmacol. 2009 Dec 1;78(11):1351-9. doi: 10.1016/j.bcp.2009.06.094. Epub 2009 Jul 1.@@Kline JP, Larson RA: Clofarabine in the treatment of acute myeloid leukaemia and acute lymphoblastic leukaemia: a review. Expert Opin Pharmacother. 2005 Dec;6(15):2711-8.@@Takahashi T, Kanazawa J, Akinaga S, Tamaoki T, Okabe M: Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration. Cancer Chemother Pharmacol. 1999;43(3):233-40. |
| Groups | Approved; Investigational |
| Direct Classification | Purine 2'-deoxyribonucleosides |
| SMILES | NC1=C2N=CN([C@H]3C[C@H](O)[C@@H](CO)O3)C2=NC(Cl)=N1 |
| Pathways | |
| PharmGKB | PA449027 |
| ChEMBL | CHEMBL1619 |
