| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30019224 | HIV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS20017037 | HPV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS20017038 | HPV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS20016521 | HPV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS20065407 | HPV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS20017039 | HPV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS20050473 | HPV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS20017040 | HPV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS44008296 | HTLV-1 | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SCNN1A |
|---|---|
| DrugBank ID | DB00384 |
| Drug Name | Triamterene |
| Target ID | BE0000190 |
| UniProt ID | P37088 |
| Regulation Type | inhibitor |
| PubMed IDs | 17139284; 17016423; 8772124; 11509829; 11752352 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Busch AE, Suessbrich H, Kunzelmann K, Hipper A, Greger R, Waldegger S, Mutschler E, Lindemann B, Lang F: Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis. Pflugers Arch. 1996 Sep;432(5):760-6.@@Wagner CA, Ott M, Klingel K, Beck S, Melzig J, Friedrich B, Wild KN, Broer S, Moschen I, Albers A, Waldegger S, Tummler B, Egan ME, Geibel JP, Kandolf R, Lang F: Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis. Cell Physiol Biochem. 2001;11(4):209-18.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved |
| Direct Classification | Pteridines and derivatives |
| SMILES | NC1=NC(N)=C2N=C(C(N)=NC2=N1)C1=CC=CC=C1 |
| Pathways | Triamterene Action Pathway |
| PharmGKB | PA451752 |
| ChEMBL | CHEMBL585 |
