| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30014605 | HIV | ENSG00000174175.17 | protein_coding | SELP | No | No | 6403 | P16109 Q5R341 Q6NUL9 |
| TVIS20029044 | HPV | ENSG00000174175.17 | protein_coding | SELP | No | No | 6403 | P16109 Q5R341 Q6NUL9 |
| TVIS20048087 | HPV | ENSG00000174175.17 | protein_coding | SELP | No | No | 6403 | P16109 Q5R341 Q6NUL9 |
| TVIS20068815 | HPV | ENSG00000174175.17 | protein_coding | SELP | No | No | 6403 | P16109 Q5R341 Q6NUL9 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SELP |
|---|---|
| DrugBank ID | DB01109 |
| Drug Name | Heparin |
| Target ID | BE0001159 |
| UniProt ID | P16109 |
| Regulation Type | inhibitor |
| PubMed IDs | 17458940; 17549299; 17629851; 17651117; 15995351; 9466983; 7694675 |
| Citations | Simonis D, Fritzsche J, Alban S, Bendas G: Kinetic analysis of heparin and glucan sulfates binding to P-selectin and its impact on the general understanding of selectin inhibition. Biochemistry. 2007 May 22;46(20):6156-64. Epub 2007 Apr 26.@@Maugeri N, Di Fabio G, Barbanti M, de Gaetano G, Donati MB, Cerletti C: Parnaparin, a low-molecular-weight heparin, prevents P-selectin-dependent formation of platelet-leukocyte aggregates in human whole blood. Thromb Haemost. 2007 Jun;97(6):965-73.@@Simonis D, Christ K, Alban S, Bendas G: Affinity and kinetics of different heparins binding to P- and L-selectin. Semin Thromb Hemost. 2007 Jul;33(5):534-9.@@Asberg AE, Videm V: Inhibition of platelet receptors involved in neutrophil-platelet interaction in model cardiopulmonary bypass. Artif Organs. 2007 Aug;31(8):617-26.@@Gao Y, Li N, Fei R, Chen Z, Zheng S, Zeng X: P-Selectin-mediated acute inflammation can be blocked by chemically modified heparin, RO-heparin. Mol Cells. 2005 Jun 30;19(3):350-5.@@Koenig A, Norgard-Sumnicht K, Linhardt R, Varki A: Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents. J Clin Invest. 1998 Feb 15;101(4):877-89.@@Nelson RM, Cecconi O, Roberts WG, Aruffo A, Linhardt RJ, Bevilacqua MP: Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation. Blood. 1993 Dec 1;82(11):3253-8. |
| Groups | Approved; Investigational |
| Direct Classification | |
| SMILES | |
| Pathways | Fc Epsilon Receptor I Signaling in Mast Cells; Heparin Action Pathway |
| PharmGKB | PA449855 |
| ChEMBL | CHEMBL1909300 |
