| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10003675 | HBV | ENSG00000115524.17 | protein_coding | SF3B1 | Yes | No | 23451 | B4DGZ4 O75533 |
| TVIS10021514 | HBV | ENSG00000115524.17 | protein_coding | SF3B1 | Yes | No | 23451 | B4DGZ4 O75533 |
| TVIS10028791 | HBV | ENSG00000115524.17 | protein_coding | SF3B1 | Yes | No | 23451 | B4DGZ4 O75533 |
| TVIS10061551 | HBV | ENSG00000115524.17 | protein_coding | SF3B1 | Yes | No | 23451 | B4DGZ4 O75533 |
| TVIS10061550 | HBV | ENSG00000115524.17 | protein_coding | SF3B1 | Yes | No | 23451 | B4DGZ4 O75533 |
| TVIS10061191 | HBV | ENSG00000115524.17 | protein_coding | SF3B1 | Yes | No | 23451 | B4DGZ4 O75533 |
| TVIS10061549 | HBV | ENSG00000115524.17 | protein_coding | SF3B1 | Yes | No | 23451 | B4DGZ4 O75533 |
| TVIS30052126 | HIV | ENSG00000115524.17 | protein_coding | SF3B1 | Yes | No | 23451 | B4DGZ4 O75533 |
| TVIS43000052 | MCV | ENSG00000115524.17 | protein_coding | SF3B1 | Yes | No | 23451 | B4DGZ4 O75533 |
| TVIS43000114 | MCV | ENSG00000115524.17 | protein_coding | SF3B1 | Yes | No | 23451 | B4DGZ4 O75533 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SF3B1 |
|---|---|
| DrugBank ID | DB14017 |
| Drug Name | H3B-8800 |
| Target ID | BE0009359 |
| UniProt ID | O75533 |
| Regulation Type | inhibitor |
| PubMed IDs | 21981285; 29457796 |
| Citations | Yokoi A, Kotake Y, Takahashi K, Kadowaki T, Matsumoto Y, Minoshima Y, Sugi NH, Sagane K, Hamaguchi M, Iwata M, Mizui Y: Biological validation that SF3b is a target of the antitumor macrolide pladienolide. FEBS J. 2011 Dec;278(24):4870-80. doi: 10.1111/j.1742-4658.2011.08387.x. Epub 2011 Oct 31.@@Seiler M, Yoshimi A, Darman R, Chan B, Keaney G, Thomas M, Agrawal AA, Caleb B, Csibi A, Sean E, Fekkes P, Karr C, Klimek V, Lai G, Lee L, Kumar P, Lee SC, Liu X, Mackenzie C, Meeske C, Mizui Y, Padron E, Park E, Pazolli E, Peng S, Prajapati S, Taylor J, Teng T, Wang J, Warmuth M, Yao H, Yu L, Zhu P, Abdel-Wahab O, Smith PG, Buonamici S: H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers. Nat Med. 2018 May;24(4):497-504. doi: 10.1038/nm.4493. Epub 2018 Feb 19. |
| Groups | Investigational |
| Direct Classification | |
| SMILES | C[C@H](C=CC=C(/C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(=O)N2CCN(C)CC2)C=C[C@@H]1C)C1=CC=CC=N1 |
| Pathways | |
| PharmGKB | |
| ChEMBL |
