| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20009899 | HPV | ENSG00000197375.14 | protein_coding | SLC22A5 | No | No | 6584 | O76082 |
| TVIS20059706 | HPV | ENSG00000197375.14 | protein_coding | SLC22A5 | No | No | 6584 | O76082 |
| TVIS44039026 | HTLV-1 | ENSG00000197375.14 | protein_coding | SLC22A5 | No | No | 6584 | O76082 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SLC22A5 |
|---|---|
| DrugBank ID | DB00583 |
| Drug Name | Levocarnitine |
| Target ID | BE0000106 |
| UniProt ID | O76082 |
| Regulation Type | |
| PubMed IDs | 12175785; 12181285; 12183691; 12635840; 12644265 |
| Citations | Lahjouji K, Elimrani I, Wu J, Mitchell GA, Qureshi IA: A heterozygote phenotype is present in the jvs +/- mutant mouse livers. Mol Genet Metab. 2002 May;76(1):76-80.@@Kristufek D, Rudorfer W, Pifl C, Huck S: Organic cation transporter mRNA and function in the rat superior cervical ganglion. J Physiol. 2002 Aug 15;543(Pt 1):117-34.@@Ohashi R, Tamai I, Inano A, Katsura M, Sai Y, Nezu J, Tsuji A: Studies on functional sites of organic cation/carnitine transporter OCTN2 (SLC22A5) using a Ser467Cys mutant protein. J Pharmacol Exp Ther. 2002 Sep;302(3):1286-94.@@Hou JW: Primary systemic carnitine deficiency presenting as recurrent Reye-like syndrome and dilated cardiomyopathy. Chang Gung Med J. 2002 Dec;25(12):832-7.@@Friedrich A, Prasad PD, Freyer D, Ganapathy V, Brust P: Molecular cloning and functional characterization of the OCTN2 transporter at the RBE4 cells, an in vitro model of the blood-brain barrier. Brain Res. 2003 Apr 4;968(1):69-79. |
| Groups | Approved; Investigational |
| Direct Classification | Carnitines |
| SMILES | C[N+](C)(C)C[C@H](O)CC([O-])=O |
| Pathways | Carnitine Palmitoyl Transferase Deficiency II; Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD); Ethylmalonic Encephalopathy; Glutaric Aciduria Type I; Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency); Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD); Carnitine Palmitoyl Transferase Deficiency I; Oxidation of Branched-Chain Fatty Acids; Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids; Fatty Acid Metabolism; Beta Oxidation of Very Long Chain Fatty Acids; Carnitine-Acylcarnitine Translocase Deficiency; Carnitine Synthesis; Trifunctional Protein Deficiency; Adrenoleukodystrophy, X-Linked; Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) |
| PharmGKB | PA450154 |
| ChEMBL | CHEMBL1149 |
