| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10017595 | HBV | ENSG00000157103.13 | protein_coding | SLC6A1 | No | No | 6529 | B7Z3C5 P30531 |
| TVIS10045285 | HBV | ENSG00000157103.13 | protein_coding | SLC6A1 | No | No | 6529 | B7Z3C5 P30531 |
| TVIS10045286 | HBV | ENSG00000157103.13 | protein_coding | SLC6A1 | No | No | 6529 | B7Z3C5 P30531 |
| TVIS30056253 | HIV | ENSG00000157103.13 | protein_coding | SLC6A1 | No | No | 6529 | B7Z3C5 P30531 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SLC6A1 |
|---|---|
| DrugBank ID | DB00906 |
| Drug Name | Tiagabine |
| Target ID | BE0000249 |
| UniProt ID | P30531 |
| Regulation Type | inhibitor |
| PubMed IDs | 11752352; 16420077; 18007567; 16377242; 20512624; 17069932 |
| Citations | Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Pollack MH, Roy-Byrne PP, Van Ameringen M, Snyder H, Brown C, Ondrasik J, Rickels K: The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study. J Clin Psychiatry. 2005 Nov;66(11):1401-8.@@Sheehan DV, Sheehan KH, Raj BA, Janavs J: An open-label study of tiagabine in panic disorder. Psychopharmacol Bull. 2007;40(3):32-40.@@Foster AC, Kemp JA: Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. Epub 2005 Dec 22.@@Sunol C, Babot Z, Cristofol R, Sonnewald U, Waagepetersen HS, Schousboe A: A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures. Neurochem Res. 2010 Sep;35(9):1384-90. doi: 10.1007/s11064-010-0196-1. Epub 2010 May 30.@@Henjum S, Hassel B: High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study. Neurochem Int. 2007 Jan;50(2):365-70. Epub 2006 Oct 27. |
| Groups | Approved; Investigational |
| Direct Classification | Piperidinecarboxylic acids |
| SMILES | CC1=C(SC=C1)C(=CCCN1CCC[C@H](C1)C(O)=O)C1=C(C)C=CS1 |
| Pathways | |
| PharmGKB | PA451682 |
| ChEMBL | CHEMBL1027 |
